Zihan Chen
The Chinese University of Hong Kong
5 Papers
17 Citations
Zihan Chen is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Deep sequencing & Leverage (statistics). The author has an hindex of 3, co-authored 4 publications.
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Papers
Deep reinforcement learning empowers automated inverse design and optimization of photonic crystals for nanoscale laser cavities
Renjie Li,Ceyao Zhang,Wentao Xie,Yuanhao Gong,Feilong Ding,Hui Dai,Zihan Chen,Feng Yin,Zhao-Qing Zhang +8 more
TL;DR: In this article , the authors propose Learning to Design Optical Resonators (L2DO) to leverage RL that learns to autonomously inverse design nanophotonic laser cavities without any prior knowledge while retrieving unique design solutions.
The role of chromosomal microarray analysis among fetuses with normal karyotype and single system anomaly or nonspecific sonographic findings
Annie Sy Hui,Matthew Hoi Kin Chau,Yiu Man Chan,Yiu Man Chan,Ye Cao,Angel Hw Kwan,Xiaofan Zhu,Yvonne K. Kwok,Zihan Chen,Terence T. Lao,Kwong Wai Choy,Tak Yeung Leung +11 more
TL;DR: This study aims to investigate the incremental diagnostic yield of chromosomal microarray over conventional karyotyping analysis in fetuses with anomalies restricted to one anatomic system and those with nonspecific anomalies detected by sonography.
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Trio-Based Low-Pass Genome Sequencing Reveals Characteristics and Significance of Rare Copy Number Variants in Prenatal Diagnosis.
Matthew Hoi Kin Chau,Jicheng Qian,Zihan Chen,Ying Li,Yu Zheng,Wing Ting Tse,Yvonne K. Kwok,Tak Yeung Leung,Zirui Dong,Kwong Wai Choy +9 more
TL;DR: In this paper, a trio-based low-pass genome sequencing (GS) was performed in 315 pregnant women undergoing invasive testing, and rare copy number variants (CNVs) detected in the fetuses were investigated.
Noninvasive prenatal sequencing for multiple Mendelian monogenic disorders among fetuses with skeletal dysplasia or increased nuchal translucency.
H. Yan,Xiaofan Zhu,Jingsi Chen,Ye Cao,Yvonne K. Kwok,Zihan Chen,Tak Yeung Leung,Min Chen,Kwong Wai Choy +8 more
TL;DR: To evaluate the performance of noninvasive prenatal sequencing for multiple Mendelian monogenic disorders (NIPS‐M) among fetuses with skeletal abnormalities or increased nuchal translucency (NT), a large number of patients were diagnosed with at least one of the disorders.
Low-pass genome sequencing: a validated method in clinical cytogenetics
Matthew Hoi Kin Chau,Huilin Wang,Yunli Lai,Yanyan Zhang,Fuben Xu,Yanqing Tang,Yanfang Wang,Zihan Chen,Tak Yeung Leung,Jacqueline Pui Wah Chung,Yvonne K. Kwok,Shuk Ching Chong,Kwong Wai Choy,Yuanfang Zhu,Likuan Xiong,Weihong Wei,Zirui Dong +16 more
TL;DR: In this article, the optimal read-amount and the most cost-effective read-length for CNV analysis to be 15 million reads and single-end 50bp (equivalent to a read-depth of 0.25-fold), respectively.