Zheng Hu
Stanford University
36 Papers
63 Citations
Zheng Hu is an academic researcher from Stanford University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 16, co-authored 33 publications. Previous affiliations of Zheng Hu include Chinese Academy of Sciences & Huazhong University of Science and Technology.
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Papers
Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution
Shaoping Ling,Zheng Hu,Z.F. Yang,Fang Yang,Yawei Li,Pei Lin,Ke Chen,Lili Dong,Lihua Cao,Yong Tao,Lingtong Hao,Qingjian Chen,Qiang Gong,Dafei Wu,Wenjie Li,Wenming Zhao,Xiuyun Tian,Chunyi Hao,Eric A. Hungate,Daniel V.T. Catenacci,Richard R. Hudson,Wen-Hsiung Li,Xuemei Lu,Chung-I Wu,Chung-I Wu,Chung-I Wu +25 more
TL;DR: A single tumor is evaluated by sequencing or genotyping nearly 300 regions from the tumor and the number of coding region mutations was estimated to be greater than 100 million in this unexceptional tumor, suggesting non-Darwinian evolution should be heeded in cancer treatments even for microscopic tumors.
374
Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases.
TL;DR: Analysis of whole-exome sequencing data from paired primary tumors and metastases from patients with breast, colorectal and lung cancer identifies clonal remodeling associated with therapy and few metastasis-private clonal mutations, consistent with early metastatic seeding.
284
Pan-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases
TL;DR: Pan-cancer analysis reveals early systemic spread in three common cancer types and suggests that the natural course of metastasis is selectively relaxed relative to early tumor development and that metastasis-private mutations are not drivers of cancer spread but instead associated with drug resistance.
SIX1 Promotes Tumor Lymphangiogenesis by Coordinating TGFβ Signals That Increase Expression of VEGF-C
Dan Liu,Li Li,Xiaoxue Zhang,Dongyi Wan,Bi-Xin Xi,Zheng Hu,Wencheng Ding,Da Zhu,Xiaoli Wang,Wei Wang,Zuo-Hua Feng,Hui Wang,Ding Ma,Qinglei Gao +13 more
TL;DR: It is reported that sine oculis homeobox homolog 1 (SIX1), expressed in tumor cells, can promote tumor lymphangiogenesis and lymph node metastasis by coordinating with TGFβ to increase the expression of VEGF-C.
93
Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
Jennifer L. Caswell-Jin,Katherine McNamara,Johannes G. Reiter,Ruping Sun,Zheng Hu,Zhicheng Ma,Jie Ding,Carlos Suárez,Susanne Tilk,Akshara Singareeka Raghavendra,Victoria Forte,Victoria Forte,Suet-Feung Chin,Helen Bardwell,Elena Provenzano,Carlos Caldas,Julie E. Lang,Robert B. West,Debasish Tripathy,Michael F. Press,Christina Curtis +20 more
TL;DR: Computational modeling based on analysis of fifteen primary breast tumors finds that apparent clonal change can in fact be due to pre-treatment heterogeneity, and samples from at least two regions are necessary to detect treatment-induced clonal shifts.