The invention discloses a type-3 DHAV (duck hepatitis A virus) mutant gene ISA-A117C and a construction method. G of 3403th nucleotide of a mutant genome is mutated into T, serves as a genetic marker of infectious clone and can be used for distinguishing a rescue strain from a parent strain and a wild strain; A of 117th nucleotide of 5'UTR is mutated into C. A virus strain of the mutant gene has the same antigenicity as the parent strain, but has higher proliferation efficiency and virus titer than the parent strain on a duck embryo and can be proliferated on a chicken embryo, and the immunogenicity and the genetic stability are good. The pathogenicity of the virus strain of the mutant gene for ducklings is notably reduced, and the virus strain can be duplicated in the ducklings, but has no pathogenicity, which lays an important foundation for a virus pathogenic mechanism and vaccine development. To sum up, the type-3 DHAV mutant gene ISA-A117C virus strain can serve as a vaccine candidate or culture toxic strain, can be used for type-3 DHAV host tropism and attenuated mechanism research and has broad application prospects.

Type-3 DHAV (duck hepatitis A virus) mutant gene ISA-T1142A-C4334A and construction method

The present invention falls within the technical field of medicine. In particular, the present invention relates to a risedronate zinc micronano-adjuvant which has a slow-release function and is formed by mineralizing the major components, zinc ions and risedronic acid, and the use of same as a vaccine adjuvant. The present invention also relates to a method for preparing the risedronate zinc micronano-adjuvant. The present invention also relates to a chemical composition, a vaccine adjuvant and a vaccine composition containing the risedronate zinc micronano-adjuvant. Furthermore, the present invention relates to the use of the risedronate zinc micronano-adjuvant as a vaccine adjuvant.

Preparation of risedronate zinc micronano-adjuvant, and use of same as vaccine adjuvant

Provided in the present invention is the use of a mevalonic acid pathway inhibitor in the preparation of a drug for treating and/or preventing tumours, inducing immunogenic death of tumour cells, inducing immune responses and activating T cells or DC cells to directly promote host immunity. Also provided in the present invention is a pharmaceutical composition comprising the mevalonic acid pathway inhibitor and an antitumour drug (for example, an immune checkpoint inhibitor and any drug that can lead to new antigen production) and a combination of the mevalonic acid pathway inhibitor and an antitumour drug (for example, an immune checkpoint inhibitor and any drug that can lead to new antigen production) and/or the radiotherapy.

Mevalonate pathway inhibitor and pharmaceutical composition thereof

Disclosed are a mevalonate pathway inhibitor as a vaccine adjuvant, and use thereof. Specifically, the inhibitor is an acetoacetyl-CoA transferase inhibitor, an HMG-CoA synthase inhibitor, an HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor, and a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition，and the composition contains the mevalonate pathway inhibitor as an adjuvant.

Mevalonate pathway inhibitor as highly-effective vaccine adjuvant

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Mevalonate pathway inhibitor as highly-effective vaccine adjuvant