Purpose: To determine, in a meta-analysis, the diagnostic performance of contrast material–enhanced magnetic resonance (MR) imaging in patients with breast lesions. Materials and Methods: Studies to assess the diagnostic performance of MR imaging in patients suspected of having breast cancer who underwent MR imaging and biopsy from January 1985 through March 2005 were reviewed for inclusion. A summary receiver operating characteristic curve was constructed, and pooled weighted estimates of sensitivity and specificity were calculated by using the recently developed bivariate approach for diagnostic meta-analysis. Results: Of 251 eligible studies, 44 were included in the meta-analysis (sample size range, 14–821; cancer prevalence, 23%–84%). Pooled weighted estimates of sensitivity and specificity were 0.90 (95% confidence interval: 0.88, 0.92) and 0.72 (95% confidence interval: 0.67, 0.77), respectively. The performance of breast MR imaging was influenced by the prevalence of cancer in the studied populatio...

Meta-Analysis of MR Imaging in the Diagnosis of Breast Lesions

Purpose: To prospectively determine the prevalence and predictive value of three-dimensional (3D) and dynamic breast magnetic resonance (MR) imaging and contrast material kinetic features alone and as part of predictive diagnostic models. Materials and Methods: The study protocol was approved by the institutional review board or ethics committees of all participating institutions, and informed consent was obtained from all participants. Although study data collection was performed before HIPAA went into effect, standards that would be compliant with HIPAA were adhered to. Data from the International Breast MR Consortium trial 6883 were used in the analysis. Women underwent 3D (minimum spatial resolution, 0.7 × 1.4 × 3 mm; minimal temporal resolution, 4 minutes) and dynamic two-dimensional (temporal resolution, 15 seconds) MR imaging examinations. Readers rated enhancement shape, enhancement distribution, border architecture, enhancement intensity, presence of rim enhancement or internal septations, and th...

Diagnostic architectural and dynamic features at breast MR imaging: Multicenter study

ContextBreast magnetic resonance imaging (MRI) has been shown to have high
sensitivity for cancer detection and is increasingly used following mammography
to evaluate suspicious breast lesions.ObjectiveTo determine the accuracy of breast MRI in conjunction with mammography
for the detection of breast cancer in patients with suspicious mammographic
or clinical findings.Design, Setting, and PatientsProspective multicenter investigation of the International Breast MR
Consortium conducted at 14 university hospitals in North America and Europe
from June 2, 1998, through October 31, 2001, of 821 patients referred for
breast biopsy for American College of Radiology category 4 or 5 mammographic
assessment or suspicious clinical or ultrasound finding.InterventionsMRI examinations performed prior to breast biopsy; MRI results were
interpreted at each site, which were blinded to pathological results.Main Outcome MeasuresArea under the receiver operating characteristic curve (AUC), sensitivity,
and specificity of breast MRI.ResultsAmong the 821 patients, there were 404 malignant index lesions, of which
63 were ductal carcinoma in situ (DCIS) and 341 were invasive carcinoma. Of
the 417 nonmalignant index lesions, 366 were benign, 47 showed atypical histology,
and 4 were lobular carcinoma in situ. The AUC pooled over all institutions
was 0.88 (95% confidence interval [CI], 0.86-0.91). MRI correctly detected
cancer in 356 of 404 cancer cases (DCIS or invasive cancer), resulting in
a sensitivity of 88.1% (95% CI, 84.6%-91.1%), and correctly identified as
negative for cancer 281 of 417 cases without cancer, resulting in a specificity
of 67.7% (95% CI, 62.7%-71.9%). MRI performance was not significantly affected
by mammographic breast density, tumor histology, or menopausal status. The
positive predictive values for 356 of 492 patients was 72.4% (95% CI, 68.2%-76.3%)
and of mammography for 367 of 695 patients was 52.8% (95% CI, 49.0%-56.6%)
(P<.005). Dynamic MRI did not improve the AUC
compared with 3-dimensional MRI alone, but the specificity of a washout pattern
for 123 of 136 patients without cancer was 90.4% (95% CI, 84%-95%).ConclusionsBreast MRI has high sensitivity but only moderate specificity independent
of breast density, tumor type, and menopausal status. Although the positive
predictive value of MRI is greater than mammography, MRI does not obviate
the need for subsequent tissue sampling in this setting.

/pdf/magnetic-resonance-imaging-of-the-breast-prior-to-biopsy-2mtzzpx637.pdf

Magnetic Resonance Imaging of the Breast Prior to Biopsy

Purpose Recent changes have occurred in the presurgical planning for breast cancer, including the introduction of preoperative breast magnetic resonance imaging (MRI). We sought to analyze the trends in mastectomy rates and the relationship to preoperative MRI and surgical year at Mayo Clinic, Rochester, MN. Patients and Methods We identified 5,405 patients who underwent surgery between 1997 and 2006. Patients undergoing MRI were identified from a prospective database. Trends in mastectomy rate and the association of MRI with surgery type were analyzed. Multiple logistic regression was used to assess the effect of surgery year and MRI on surgery type, while adjusting for potential confounding variables. Results Mastectomy rates differed significantly across time (P < .0001), and decreased from 45% in 1997% to 31% in 2003, followed by increasing rates for 2004 to 2006. The use of MRI increased from 10% in 2003% to 23% in 2006 (P < .0001). Patients with MRI were more likely to undergo mastectomy than those ...

Trends in Mastectomy Rates at the Mayo Clinic Rochester: Effect of Surgical Year and Preoperative Magnetic Resonance Imaging

Purpose
To investigate the potential of apparent diffusion coefficients (ADCs) in characterizing breast lesions in vivo.

Materials and Methods
Two diffusion-weighted (DW) sequences were implemented on a 1.5 Tesla scanner, with low b-value orthogonal and high b-value tetrahedral sensitized sequences. The orthogonal sequence was evaluated on 16 normal volunteers and 23 patients with known lesion types (six benign and 17 malignant). The tetrahedral sequence was evaluated on a smaller number of subjects: two normal, two malignant, and two benign.

Results
The mean value of the ADC of the malignant tumors was reduced compared to that of the benign lesions and normal tissue. This finding was related to the increased cellularity of the malignant lesions. The ADC values were elevated for all tissue types with the low b-value sequence as compared to the high b-value sequence, indicating contributions from perfusion effects at the low b-values.

Conclusion
The study clearly shows that DW-MRI can help characterize breast lesions in vivo. J. Magn. Reson. Imaging 2002;15:693–704. © 2002 Wiley-Liss, Inc.

In vivo diffusion-weighted MRI of the breast: potential for lesion characterization.

Purpose: To determine the sensitivity and specificity of X-ray mammography and of MR imaging in 238 consecutively operated breasts, and to correlate the findings to histopathological diagnosis.Material and Methods: Over 15 months, 220 patients scheduled for breast surgery were examined consecutively, before surgery, by means of both mammography and MR imaging. of the 220 patients, 18 underwent bilateral breast surgery. The entire breast was examined by means of T1-weighted transversal images using a 3D fast low-angle shot (FLASH) sequence. One pre— and 2 post-contrast scans were performed. Each breast was examined by means of mammography and 3 views were applied as routine. All palpable and mammographically suspect lesions were examined on additional images as microfocus magnification or spot compression. The two methods were evaluated independently of each other.Results: In total, 145 malignant and 93 benign lesions were found at histopathological examination. The sensitivity of mammography was 89% and M...

Diagnostic accuracy of mammography and contrast-enhanced MR imaging in 238 histologically verified breast lesions.

Popular Tasks used by Researchers

How can I help with your research?

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

We encountered an error while loading the panel. Please try refreshing the page.

Something went wrong

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

Anyone with the link can view this chat. You can switch it back to private anytime.

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Z. Péntek

Author Tools

Chat about Author

Papers

Diagnostic accuracy of mammography and contrast-enhanced MR imaging in 238 histologically verified breast lesions.