Yuka Okada
Wakayama Medical University
149 Papers
927 Citations
Yuka Okada is an academic researcher from Wakayama Medical University. The author has contributed to research in topics: Corneal epithelium & Wound healing. The author has an hindex of 29, co-authored 133 publications.
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Papers
Fibrotic disorders in the eye: targets of gene therapy.
Shizuya Saika,Osamu Yamanaka,Takayoshi Sumioka,Takeshi Miyamoto,Ken-ichi Miyazaki,Yuka Okada,Ai Kitano,Kumi Shirai,Sai-ichi Tanaka,Kazuo Ikeda +9 more
TL;DR: Modulation of signal transduction molecules, e.g., Smad and mitogen-activated protein kinases, by gene transfer and other technology is beneficial and can be an important treatment regiment to overcome fibrotic diseases in the eye.
168
Immunolocalization of Prolyl 4-Hydroxylase Subunits, α-Smooth Muscle Actin, and Extracellular Matrix Components in Human Lens Capsules with Lens Implants
Shizuya Saika,Yoshiji Kawashima,Takeshi Miyamoto,Yuka Okada,Sai-ichi Tanaka,Shunsaku Ohmi,Ayako Minamide,Osamu Yamanaka,Yoshitaka Ohnishi,Akira Ooshima,Akio Yamanaka +10 more
TL;DR: During wound healing of the lens capsule after cataract extraction, the lens epithelial cells that proliferate on the inner surface of the capsule transform it into a myofibroblastic phenotype, expressing prolyl 4-hydroxylase and alpha-smooth muscle actin.
125
Smad translocation and growth suppression in lens epithelial cells by endogenous TGFbeta2 during wound repair
TL;DR: Endogenous TGF beta2 affects lens cells during wound repair after anterior capsule injury, inhibiting lens cell proliferation during the early phase, and nuclear translocation of Smads in lens epithelial cells is transient even with continuous exposure to TGFbeta2.
118
TGF beta in fibroproliferative diseases in the eye.
Shizuya Saika,Osamu Yamanaka,Yuka Okada,Sai-ichi Tanaka,Takeshi Miyamoto,Takayoshi Sumioka,Ai Kitano,Kumi Shirai,Kazuo Ikeda +8 more
TL;DR: Although various cytokine signaling pathways are involved in the fibrogenic reaction in tissues, TGF beta/Smad signal is the critical one and blocking Smad signal by chemical or natural inhibitors or anti-Smad gene introduction effectively suppress fibrogensic reaction.
110
TRPV1 Involvement in Inflammatory Tissue Fibrosis in Mice
Yuka Okada,Peter S. Reinach,Kumi Shirai,Ai Kitano,Winston W.-Y. Kao,Kathleen C. Flanders,Masayasu Miyajima,Hongshan Liu,Jianhua Zhang,Shizuya Saika +9 more
TL;DR: In conclusion, absence or blocking of TRPV1 suppressed inflammation and fibrosis/scarring during healing of alkali-burned mouse cornea and is a potential drug target for improving the outcome of inflammatory/fibrogenic wound healing.