A novel dithiourea-appended naphthalimide "on-off" fluorescent probe for detecting Hg2+ and Ag+ and its application in cell imaging.

An efficient new dual fluorescent pyrene based chemosensor for the detection of bismuth (III) and aluminium (III) ions and its applications in bio-imaging

Recent advances in fixation of CO2 into organic carbamates through multicomponent reaction strategies

According to the current need of manufacturing healthier products, food companies are seeking specific biomolecules that may offer additional added value (i.e., biological activities) to the new food formulations. Capsaicin, as the pungent ingredient of chili peppers, has become so far one of the target biomolecules explored since the 1950s. There is evidence demonstrating that capsaicin exhibits important biological properties in human health including inhibits acid secretion, stimulates alkali and mucus secretion and particularly gastric mucosal blood flow contributing to the prevention and healing of gastric ulcers, thermoregulation, among many other reported bioactivities. However, one of the main bottlenecks deals with the proper protocol of extraction and purification of this compound since most of the conventional methods based on solvent extraction do not provide efficient yield, along with diminished bioactivity of the compounds. Therefore, this review comprehensively elucidates the current strategies proposed by researchers towards the sustainable extraction and purification of capsaicin from its natural source, and comparison over traditional extraction methods. Particular emphasis has been focused on the innovative extraction techniques and the relevant insights over the last five years. A detailed discussion is provided on the advantages and drawbacks of the novel techniques, key interactions with target molecules and their effect on the bioactivity of capsaicin. To finalize, according to the findings of this review, the future trends, perspectives, and research gaps are also given. • A last 5 years comprehensive review on the current strategies towards capsaicin extraction is given. • Innovative techniques for the purification of capsaicin are highlighted. • The guidelines to the new scientists for the effective extraction are stated. • The current research gaps and perspectives in the field are outlined. 

Up-to-date strategies and future trends towards the extraction and purification of Capsaicin: A comprehensive review

Direct Access to Trifluoromethyl-Substituted Carbamates from Carbon Dioxide via Copper-Catalyzed Cascade Cyclization of Enynes.

A novel bicoumarin-based fluorescent and colorimetric probe 7,7′-(acetoxy)-3,3′-(p-phenylene)bis(coumarin) (apbis-c) for the highly sensitive detection of amines/ammonia in solution and ammonia vapor in air was constructed for the first time by using the Perkin reaction between 1,4-phenylenediacetic acid and 2,4-dihydroxybenzaldehyde. Instant color changes and real-time fluorescence responses were observed for apbis-c after treatment with different primary and secondary aliphatic amines as well as ammonia in THF/DMSO. Paper-based sensors were prepared by simply depositing apbis-c on filter paper and used in the highly selective and sensitive detection of ammonia vapor in air with an experimental detection limit of 6.85 ppm (the calculated LOD is 0.71 ppm). A plausible mechanism for the fluorescence and colorimetric responses of apbis-c to ammonia was proposed based on 1H NMR study and DFT calculations. In addition, practical studies revealed that apbis-c could be used for the preparation of fluorescent invisible ink, food spoilage indicators and naked eye sensors for lysine/arginine.

A novel bicoumarin-based multifunctional fluorescent probe for naked-eye sensing of amines/ammonia

The objective of this study was to develop a consecutive preparation method for the isolation and purification of hainanmurpanin, meranzin, and phebalosin from leaves of Murraya exotica L. The process involved supercritical fluid extraction with CO2 , solvent extraction, and two-step high-speed countercurrent chromatography. Pressure, temperature, and the volume of entrainer were optimized as 27 MPa, 52°C, and 60 mL by response surface methodology in supercritical fluid extraction with CO2 , and the yield of the crude extracts was 7.91 g from 100 g of leaves. Subsequently, 80% methanol/water was used to extract and condense the three compounds from the crude extracts, and 4.23 g of methanol/water extracts was obtained. Then, a two-step high-speed countercurrent chromatography procedure was developed for the isolation of the three target compounds from methanol/water extracts, including conventional high-speed countercurrent chromatography for further enrichment and consecutive high-speed countercurrent chromatography for purification. The yield of concentrates from high-speed countercurrent chromatography was 2.50 g from 4.23 g of methanol/water extracts. Finally, the consecutive high-speed countercurrent chromatography produced 103.2 mg of hainanmurpanin, 244.7 mg of meranzin, and 255.4 mg of phebalosin with purities up to 97.66, 99.36, and 98.64%, respectively, from 900 mg of high-speed countercurrent chromatography concentrates in one run of three consecutive sample loadings without exchanging a solvent system.

Preparative isolation and purification of hainanmurpanin, meranzin, and phebalosin from leaves of Murraya exotica L. using supercritical fluid extraction combined with consecutive high‐speed countercurrent chromatography

SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice

Visible Light-Triggered and Catalyst- and Template-Free syn-Selective [2 + 2] Cycloaddition of Chalcones: Solid-State Suspension Reaction in Water to Access syn-Cyclobutane Diastereomers

Supercritical fluid extraction with CO2 (SFE-CO2 ) was utilized for extraction of capsaicin (CA) and dihydrocapsaicin (DHCA) from Capsici Fructus, and then a two-step enrichment method for separating capsaicinoids from SFE-CO2 extracts was developed. The process involved extraction with aqueous methanol and crystallization by alkali extraction and acid precipitation. Finally, a consecutive high-speed countercurrent chromatography (HSCCC) separation method was successfully applied in the purification of CA and DHCA from capsaicinoid crystal.; Results: The extraction pressure, extraction temperature and volume of co-solvent were optimized at 33 MPa, 41 °C and 75 mL, respectively, using response surface methodology; the extraction rates of CA and DHCA were about 93.18% and 93.49%, respectively. 407.43 mg capsaicinoid crystal was isolated from the SFE-CO2 extracts obtained from 100 g capsicum powder by the two-step enrichment method. About 506 mg and 184 mg CA and DHCA with purities up to 98.31% and 96.68%, respectively, were obtained from 1 g capsaicinoid crystal in one HSCCC of three consecutive sample loadings without exchanging any solvent system.; Conclusions: This method comprising SFE-CO2 , a two-step enrichment and HSCCC was efficient, powerful and practical for the large-scale preparation of CA and DHCA from Capsici Fructus with high purity and high yield. © 2017 Society of Chemical Industry.; © 2017 Society of Chemical Industry.

Preparative isolation and purification of capsaicin and dihydrocapsaicin from Capsici Fructus using supercritical fluid extraction combined with high speed countercurrent chromatography.

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