21 Papers
17 Citations
Ye Gu is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Osteoclast & Osteolysis. The author has an hindex of 5, co-authored 10 publications.
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Papers
Inhibition of titanium-particle-induced inflammatory osteolysis after local administration of dopamine and suppression of osteoclastogenesis via D2-like receptor signaling pathway.
Huilin Yang,Yaozeng Xu,Mo Zhu,Ye Gu,Wen Zhang,Hongguo Shao,Yijun Wang,Zichuan Ping,Xuanyang Hu,Liangliang Wang,Dechun Geng +10 more
TL;DR: Dopamine therapy could be developed into an effective and safe method for osteolysis-related disease caused by chronic inflammation and excessive osteoclast formation.
90
TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss
Chen Yang,Huaqiang Tao,Haiming Zhang,Yuzhong Xia,Jiaxiang Bai,Gaoran Ge,Wenming Li,Wei Zhang,Long Xiao,Yaozeng Xu,Zhirong Wang,Ye Gu,Huilin L. Yang,Yu Liu,Dechun Geng +14 more
TL;DR: Evidence is provided that TET2 promotes osteoclast differentiation by inhibiting BCL2 expression and positively regulating BECN1-dependent autophagy, and the LV-shTet2 lentivirus prevented bone loss in OVX mice.
52
Acetyl-11-keto-β-boswellic acid attenuates titanium particle-induced osteogenic inhibition via activation of the GSK-3β/β-catenin signaling pathway.
Longbin Xiong,Yu Liu,Feng Zhu,Jiayi Lin,Dongxiang Wen,Dongxiang Wen,Zhen Wang,Jiaxiang Bai,Gaoran Ge,Congxin Xu,Ye Gu,Yaozeng Xu,Jun Zhou,Dechun Geng +13 more
TL;DR: Acetyl-11-keto-β-boswellic acid (AKBA) treatment significantly inhibited titanium particle-induced osteogenic inhibition by enhancing osteogenesis both in vivo and in vitro, suggesting that AKBA is a promising new target in the prevention and treatment of PPO.
30
Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages
Huaqiang Tao,Yunxia Tao,Chen Yang,Wenming Li,Wei Zhang,Xueyan Li,Ye Gu,Yujing Hong,Huilin L. Yang,Yu Liu,Xing Yang,Dechun Geng +11 more
TL;DR: Uro-A is a robust and effective treatment for preventing senile osteoporosis bone loss and in a mouse model of aging, it effectively inhibited bone loss in the proximal femur, spine and tibia of aging mice.
20
Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling.
Ning Li,Xiaoping Li,Kai Zheng,Jiaxiang Bai,Weicheng Zhang,Houyi Sun,Gaoran Ge,Wei Wang,Zhen Wang,Ye Gu,Yi Xue,Yaozeng Xu,Dechun Geng,Jun Zhou +13 more
TL;DR: In this paper, the impact of the SIRT3 on titanium particle-induced osteolysis was explored, and it was found that the inhibition of SIRT-3 suppressed nuclear factor-κB ligand (RANKL)-mediated osteoclasts activation in a dose-dependent fashion.