Yang Chen
Harbin Medical University
22 Papers
45 Citations
Yang Chen is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Viral replication & Coxsackievirus. The author has an hindex of 10, co-authored 20 publications.
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Papers
Knowledge, attitude and practice of antibiotics: a questionnaire study among 2500 Chinese students
Ying Huang,Jiarui Gu,Mingyu Zhang,Zheng Ren,Weidong Yang,Yang Chen,Yingmei Fu,Xiaobei Chen,Jochen W L Cals,Fengmin Zhang +9 more
TL;DR: This study indicates that Chinese medical curriculum significantly improves students’ knowledge on antibiotics and raises their attention on antibiotic resistance that may result from indiscriminate use of antibiotics.
Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.
Yingmei Fu,Wenli Zhang,Hong Wang,Song Zhao,Yang Chen,Fanfei Meng,Ying Zhang,Hui Xu,Xiaobei Chen,Fengmin Zhang +9 more
TL;DR: Resistance rate to ciprofloxac in and levofloxacin were statistically different among clinical isolates of Enterobacteriaceae harboring GyrA mutations, and Ser83Leu+Asp87Asn may account for the antimicrobial resistance difference between ciproprofl oxacin and lev ofl Oxacin.
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Yan Wang,Ying Qin,Tianying Wang,Yang Chen,Xiujuan Lang,Jia Zheng,Shuoyang Gao,Sijia Chen,Xiaoyan Zhong,Yusong Mu,Xiaoyu Wu,Fengming Zhang,Wenran Zhao,Zhaohua Zhong +13 more
TL;DR: Results indicate that pyroptosis is involved in the pathogenesis of both EV71 and CVB3 infections, and the treatment of caspase-1 inhibitor is beneficial to the host response during enterovirus infection.
MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.
Yanru Fei,Anita Chaulagain,Tianying Wang,Yang Chen,Jinchang Liu,Ming Yi,Ying Wang,Yike Huang,Lexun Lin,Sijia Chen,Weizhen Xu,Lei Tong,Xiaoyu Wu,Dechao Zhao,Fengmin Zhang,Wenran Zhao,Zhaohua Zhong +16 more
TL;DR: The elevated miR-146a inhibited NF-κB translocation and subsequently down-regulated proinflammatory cytokine expression in the CVB3-infected cells, suggesting MiR- 146a may be a negative regulator on inflammatory response and an intrinsic protective factor in CVB infection.
Protein 2B of Coxsackievirus B3 Induces Autophagy Relying on Its Transmembrane Hydrophobic Sequences
Heng Wu,Xia Zhai,Yang Chen,Ruixue Wang,Lexun Lin,Sijia Chen,Tianying Wang,Xiaoyan Zhong,Xiaoyu Wu,Yan Wang,Fengmin Zhang,Wenran Zhao,Zhaohua Zhong +12 more
TL;DR: It is reported that protein 2B, one of the non-structural proteins of CVB3, possesses autophagy-inducing capability, and it is demonstrated that a single amino acid substitution in the stem loop in between the two hydrophobic regions ofprotein 2B abolished the formation of autophagosomes.
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