Mind, Self and Society from the Standpoint of a Social Behaviorist

Cartesian Meditations: An Introduction to Phenomenology

Submitted in partial fulfilment of the requirements for the degree
PHILOSOPHIAE DOCTOR
(LEARNING SUPPORT, GUIDANCE AND COUNSELLING)

Narratives of differently abled persons : informing career guidance policy

Background
Recent initiatives have emphasized the ongoing need to include children in healthcare research, which is relevant to the development of both paediatric and mental healthcare services. Our aim was to contribute children and their parents' perceptions and experiences of Child and Adolescent Mental Health Services (CAMHS), with the objective of providing guidance for those wishing to improve inclusivity and empowerment.

Method
We performed a thematic analysis of interview data taken from 11 children (9 boys, 2 girls, aged 8–12) and their parents (12 mothers, 2 fathers), who had recently been referred to CAMHS for mental health and educational problems.

Results
Three core themes emerged from the data. Fear of the unknown refers to emotional apprehension due to uncertainty of what happens in CAMHS. However children also provided useful reassurances for future service users. Therapeutic engagement refers to the importance of being listened to and building up good relationships with professionals. Finally making services acceptable was discussed in terms of issues of accessibility, session tolerances and suggestions for the development of child-centred services.

Conclusions
Children were able to provide potentially useful opinions of CAMHS. In a time of limited resources it is imperative that the voices of children and their parents are acknowledged in order to improve accessibility and experiences within CAMHS.

'They're not witches. …' Young children and their parents' perceptions and experiences of Child and Adolescent Mental Health Services.

Purpose – The purpose of this paper is to investigate how, and the extent to which, massive open online courses (MOOCs) might be used in the accreditation of students’ prior learning, in programme delivery at international branch campuses, and for lecturers’ professional development (PD) in transnational higher education. Design/methodology/approach – The data were obtained from two international branch campuses in the United Arab Emirates. The research adopted a qualitative methodology that involved 20 lecturers participating in semi-structured interviews and ten lecturers participating in a focus group. A rigorous process of content analysis was used to analyse and interpret the data. Findings – Lecturers in transnational higher education perceived that MOOCs were not suitable for accredited prior learning but that they might be useful as a supplementary resource for student learning and for personal PD. There was a strong belief that as international branch campuses offered a commodified product, MOOCs...

/pdf/the-use-of-moocs-in-transnational-higher-education-for-2qq6skj9tl.pdf

The use of MOOCs in transnational higher education for accreditation of prior learning, programme delivery, and professional development

This paper attempts to give a brief introduction to interpretivism, constructionism and constructivism. Similarities and differences between interpretivism and constructionism in terms of their histories and branches, ontological and epistemological stances, as well as research applications are highlighted. This review shows that whereas interpretivism can be viewed as a relatively mature orientation that contains various traditions, constructionism is a looser trend in adolescent research, and in the narrow sense denotes the "pure" relativist position, which refers to a discursive approach of theory and research. Both positions call for the importance of clearly identifying what type of knowledge and knowledge process the researcher is going to create, and correctly choosing methodology matching with the epistemological stance. Examples of adolescent research adopting interpretivist and constructionist orientations are presented.

/pdf/applications-of-interpretive-and-constructionist-research-b7fns8c0vl.pdf

Applications of interpretive and constructionist research methods in adolescent research: philosophy, principles and examples.

Polyphyllin D induces G2/M Cell Cycle Arrest via Dysfunction of Cholesterol Biosynthesis in Liver Cancer Cells.

Objective
Programmed cell death 6 (PDCD6), a Ca 2+-binding protein, has been reported to be aberrantly expressed in all kinds of tumors. The aim of this study was to explore the role and mechanism of PDCD6 in hepatocellular carcinomas (HCCs).


Methods
The expression levels of PDCD6 in liver cancer patients and HCC cell lines were analyzed using bioinformatics and Western blotting. Cell viability and metastasis were determined by methylthiazol tetrazolium (MTT) and transwell assays, respectively. And Western blotting was used to test related biomarkers and molecular pathway factors in HCC cell lines. LY294002, a PI3K inhibitor inhibiting AKT, was used to suppress the AKT/GSK3β/β-catenin pathway to help evaluate the role of this pathway in the HCC carcinogenesis associated with PDCD6.


Results
The analysis of The Cancer Genome Atlas Database suggested that high PDCD6 expression levels were relevant to liver cancer progression. This was consistent with our finding of higher levels of PDCD6 expression in HCC cell lines than in normal hepatocyte cell lines. The results of MTT, transwell migration, and Western blotting assays revealed that overexpression of PDCD6 positively regulated HCC cell proliferation, migration, and invasion. Conversely, the upregulation of PDCD6 expression in the presence of an AKT inhibitor inhibited HCC cell proliferation, migration, and invasion. In addition, PDCD6 promoted HCC cell migration and invasion by epithelial-mesenchymal transition. The mechanistic investigation proved that PDCD6 acted as a tumor promoter in HCC through the AKT/GSK3β/β-catenin pathway, increasing the expression of transcription factors and cellular proliferation and metastasis.


Conclusion
PDCD6 has a tumor stimulative role in HCC mediated by AKT/GSK3β/β-catenin signaling and might be a potential target for HCC progression.

PDCD6 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis through the AKT/GSK3β/β-catenin Pathway.

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Papers

Applications of interpretive and constructionist research methods in adolescent research: philosophy, principles and examples.

Polyphyllin D induces G2/M Cell Cycle Arrest via Dysfunction of Cholesterol Biosynthesis in Liver Cancer Cells.

PDCD6 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis through the AKT/GSK3β/β-catenin Pathway.