Yading Zhong
Anhui Medical University
5 Papers
Yading Zhong is an academic researcher from Anhui Medical University. The author has contributed to research in topics: Proband & Male infertility. The author has an hindex of 5, co-authored 5 publications.
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Papers
Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice.
Xiaojin He,Chunyu Liu,Xiaoyu Yang,Mingrong Lv,Mingrong Lv,Xiaoqing Ni,Xiaoqing Ni,Qiang Li,Qiang Li,Huiru Cheng,Wangjie Liu,Wangjie Liu,Shixiong Tian,Huan Wu,Huan Wu,Yang Gao,Yang Gao,Chenyu Yang,Qing Tan,Jiangshan Cong,Dongdong Tang,Dongdong Tang,Jingjing Zhang,Jingjing Zhang,Bing Song,Bing Song,Yading Zhong,Hang Li,Weiwei Zhi,Xiaohong Mao,Feifei Fu,Lei Ge,Qunshan Shen,Manyu Zhang,Hexige Saiyin,Li Jin,Yuping Xu,Yuping Xu,Ping Zhou,Ping Zhou,Zhaolian Wei,Zhaolian Wei,Feng Zhang,Feng Zhang,Yunxia Cao,Yunxia Cao +45 more
TL;DR: The findings in humans and mice strongly suggest that CFAP58 plays a vital role in sperm flagellogenesis and demonstrate that bi-allelic loss-of-function variants in CFAP 58 can cause axoneme and peri-axoneme malformations leading to male infertility.
99
Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and Mice.
Chunyu Liu,Xiaojin He,Wangjie Liu,Wangjie Liu,Shenmin Yang,Lingbo Wang,Weiyu Li,Weiyu Li,Huan Wu,Shuyan Tang,Xiaoqing Ni,Jiaxiong Wang,Yang Gao,Shixiong Tian,Shixiong Tian,Lin Zhang,Jiangshan Cong,Z. Zhang,Qing Tan,Jingjing Zhang,Hong Li,Yading Zhong,Mingrong Lv,Jinsong Li,Li Jin,Yunxia Cao,Feng Zhang,Feng Zhang +27 more
TL;DR: Bi-allelic mutations in TTC29, as an important genetic pathogeny, can induce MMAF-related asthenoteratospermia and provide effective guidance for clinical diagnosis and assisted reproduction treatments.
91
Homozygous mutations in SPEF2 induce multiple morphological abnormalities of the sperm flagella and male infertility.
Chunyu Liu,Mingrong Lv,Xiaojin He,Yong Zhu,Amir Amiri-Yekta,Weiyu Li,Huan Wu,Zine-Eddine Kherraf,Zine-Eddine Kherraf,Wangjie Liu,Jingjing Zhang,Qing Tan,Shuyan Tang,Yong-Jun Zhu,Yading Zhong,Caihua Li,Shixiong Tian,Zhiguo Zhang,Li Jin,Pierre F. Ray,Pierre F. Ray,Feng Zhang,Yunxia Cao +22 more
TL;DR: Functional analyses suggested that the deficiency of SPEF2 in the mutated subjects could alter the localisation of other axonemal proteins in the spermatozoa fromSPEF2-affected subjects.
82
A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia
Xiaoqing Ni,Xiaoqing Ni,Jiajia Wang,Jiajia Wang,Mingrong Lv,Chunyu Liu,Yading Zhong,Shixiong Tian,Shixiong Tian,Huan Wu,Huan Wu,Huiru Cheng,Huiru Cheng,Yang Gao,Yang Gao,Qing Tan,Qing Tan,Beili Chen,Beili Chen,Qiang Li,Bing Song,Zhaolian Wei,Zhaolian Wei,Ping Zhou,Ping Zhou,Xiaojin He,Xiaojin He,Feng Zhang,Feng Zhang,Yunxia Cao,Yunxia Cao +30 more
TL;DR: WDR19 is identified as a novel pathogenic gene for male infertility caused by asthenoteratospermia in the absence of other ciliopathic phenotypes, and that patients carrying WDR19 variant can have favorable pregnancy outcomes following ICSI.
65
Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF.
Mingrong Lv,Wangjie Liu,Wangfei Chi,Xiaoqing Ni,Jiajia Wang,Huiru Cheng,Weiyu Li,Shenmin Yang,Huan Wu,Junqiang Zhang,Yang Gao,Chunyu Liu,Caihua Li,Chenyu Yang,Qing Tan,Dongdong Tang,Jingjing Zhang,Bing Song,Yujie Chen,Qiang Li,Yading Zhong,Z. Zhang,Hexige Saiyin,Li Jin,Yuping Xu,Ping Zhou,Zhaolian Wei,Chuanmao Zhang,Xiaojin He,Feng Zhang,Yunxia Cao +30 more
TL;DR: This study strongly suggests that homozygous DZIP1 mutations can induce asthenoteratospermia with severe MMAF, and induces sperm centrioles dysfunction and causes the absence of flagella.