Objectives
To report 26 cases of fulminant type 1 diabetes found in Guangdong Medical College Futian Hospital and Central South University Second Xiangya Hospital in China and to study the difference between Chinese and Japanese patients.
Methods
The clinical and biochemical characteristics of 26 patients who had been diagnosed with fulminant type 1 diabetes mellitus in China were analyzed retrospectively and then compared with those characteristics of 161 patients from a nationwide survey in Japan at the time of diagnosis and follow-up 6 months.
Results
The mean values of the characteristics from these two data sets, including fasting and postprandial serum C-peptide concentration, serum sodium and potassium level, positive for GADAb were significantly different (P = 0.003, P = 0.005, P = 0.035, P = 0.030, P < 0.001, respectively).
Conclusions
The clinical and biochemical characteristics of Chinese patients did not largely differ from those of Japanese patients. Further studies are needed for some unique characteristics found in our group.

Clinical analysis of fulminant type 1 diabetes in China and comparison with a nationwide survey in Japan

Objectives To report 26 cases of fulminant type 1 diabetes found in Guangdong Medical College Futian Hospital and Central South University Second Xiangya Hospital in China and to study the difference between Chinese and Japanese patients. Methods The clinical and biochemical characteristics of 26 patients who had been diagnosed with fulminant type 1 diabetes mellitus in China were analyzed retrospectively and then compared with those characteristics of 161 patients from a nationwide survey in Japan at the time of diagnosis and follow-up 6 months. Results The mean values of the characteristics from these two data sets, including fasting and postprandial serum C-peptide concentration, serum sodium and potassium level, positive for GADAb were significantly different ( P  = 0.003, P  = 0.005, P  = 0.035, P  = 0.030, P Conclusions The clinical and biochemical characteristics of Chinese patients did not largely differ from those of Japanese patients. Further studies are needed for some unique characteristics found in our group.

Clinical analysis of fulminant type 1 diabetes in China and comparison with a nationwide survey in Japan.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110280

Prevalence of depressive symptoms and associated factors during the COVID-19 pandemic: A national-based study

A novel mutation of KCNJ11 gene in a patient with permanent neonatal diabetes mellitus

To explore the relationship of phenotype and genotype of neonatal diabetes mellitus (NDM) in southwestern China. Sixteen cases of NDM admitted to Children’s Hospital of Chongqing Medical University from May 2009 to May 2019 were included in this study. The clinical features of the included infants were retrospectively analyzed. Peripheral blood samples of the patients and their parents were collected for mutation detection. Among the 16 cases of NDM, 8 cases were permanent neonatal diabetes mellitus (PNDM) (including 3 clinical syndromes), and 3 cases were transient neonatal diabetes mellitus (TNDM). Mutation detection was performed in six cases. The mutation genes and their loci were FOXP3 p.V408M, KCNJ11 p.C166Y, ABCC8 p.S830P, KCNJ11 p.I182T, KCNJ11 p.G334D, and ZFP57 p.R125X,412. ABCC8 p.S830P was the new found pathogenic site of gene mutation. According to the clinical features and follow-up results, one case was diagnosed as IPEX syndrome, two as DEND syndrome, two as simple PNDM, and one as TNDM. All the TNDM could spontaneously alleviate and then insulin was withdrawn. In PNDM, 75% of those with KATP channel gene mutation could be completely or partially converted to oral sulfonylureas treatment, however, the rest cases needed lifelong insulin replacement therapy. The clinical manifestations and treatment regimens of patients with NDM vary according to the type of gene mutation. Even the same mutant genotype has differences in phenotype and response to treatment.

Clinical features and partial proportional molecular genetics in neonatal diabetes mellitus: a retrospective analysis in southwestern China.

Correspondence X. Xiao Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College 100730 Beijing P. R. China Tel.: + 86 / 10 / 6529 50 73 Fax: + 86/10/6529 40 70 xiaoxinhua@medmail.com.cn Transfer from Insulin to Sulfonylurea Treatment in a Chinese Patient with Permanent Neonatal Diabetes Mellitus due to a KCNJ11 R201H Mutation

Transfer from insulin to sulfonylurea treatment in a chinese patient with permanent neonatal diabetes mellitus due to a KCNJ11 R201H mutation.

This study aimed to investigate the association between depressive symptoms and diet- and lifestyle-related behaviors among adolescents. Cross-sectional study. Our study used stratified random cluster sampling method to recruit 6,251 adolescents aged 11–19 years as samples for research and analysis. The Center for Epidemiological Studies Depression Scale was used to assess depressive symptoms. Chi-squared test, t test, and logistic regression were used to explore the diet and lifestyle factors of depressive symptoms. Backpropagation (BP) neural network model was used to investigate the ranking of diet and lifestyle behaviors factors of depressive symptoms. The prevalence of depressive symptoms among adolescents was 32.1%. Multivariable logistic regression was used to determine 10 important variables of depressive symptoms. After ranking the importance by BP neural network, the top three important variables were found, which were sleep duration (100%), screen time (49.1%), and breakfast (23.6%). Sleep duration, screen time, and breakfast were associated factors with the most significant impacts on depressive symptoms. 

The cross-sectional study of depressive symptoms and associated factors among adolescents by backpropagation neural network.

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Transfer from insulin to sulfonylurea treatment in a chinese patient with permanent neonatal diabetes mellitus due to a KCNJ11 R201H mutation.

The cross-sectional study of depressive symptoms and associated factors among adolescents by backpropagation neural network.