Xueping Fan
Boston Medical Center
28 Papers
113 Citations
Xueping Fan is an academic researcher from Boston Medical Center. The author has contributed to research in topics: Podocyte & Kidney disease. The author has an hindex of 13, co-authored 24 publications. Previous affiliations of Xueping Fan include Boston University & University of Pennsylvania.
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Papers
Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline.
TL;DR: Evidence is presented that the SH3-SH2 adaptor protein Dreadlocks, the p21-activated serine-threonine kinase (Pak), and the Rac1/Rac2/Mtl small GTPases can function during Robo repulsion and that Rac can function in both attractive and repulsive axon guidance.
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Oligomerization of polyalanine expanded PABPN1 facilitates nuclear protein aggregation that is associated with cell death
TL;DR: It is suggested that oligomerization of PABPN1 plays a crucial role in the formation of O PMD nuclear protein aggregation, while the expanded polyalanine stretch is necessary but not sufficient to induce OPMDprotein aggregation, and that the nuclearprotein aggregation might be toxic and cause cell death.
MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus
Fabiola Quintero-Rivera,Qiongchao J. Xi,Kim M. Keppler-Noreuil,Ji Hyun Lee,Anne W. Higgins,Raymond M. Anchan,Amy E. Roberts,Ihn Sik Seong,Xueping Fan,Kasper Lage,Lily Y. Lu,Joanna Tao,Xuchen Hu,Ronald Berezney,Bruce D. Gelb,Anna Kamp,Ivan P. Moskowitz,Ronald V. Lacro,Weining Lu,Cynthia C. Morton,James F. Gusella,Richard L. Maas +21 more
TL;DR: Significant perturbations in Matrin 3 expression appear to cause similar LVOT defects in human and mouse, as well as ventricular septal defect (VSD) and double-outlet right ventricle (DORV).
Schwannomin isoform-1 interacts with syntenin via PDZ domains.
Mehrdad Jannatipour,Patrick A. Dion,Saad A. Khan,Hitesh K. Jindal,Xueping Fan,Janet Laganière,Athar H. Chishti,Guy A. Rouleau +7 more
TL;DR: Using the yeast two-hybrid system, syntenin is identified as a binding partner for schwannomin isoform-1 (sch-1) and it is showed that the two proteins interact in vitro and in vivo and localized underneath the plasma membrane.
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Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure
Xueping Fan,Qinggang Li,Anna Pisarek-Horowitz,Hila Milo Rasouly,Xiangling Wang,Ramon G. Bonegio,Hang Wang,Margaret McLaughlin,Steve Mangos,Raghu Kalluri,Lawrence B. Holzman,Iain A. Drummond,Dennis Brown,David J. Salant,Weining Lu +14 more
TL;DR: It is reported that Robo2 is expressed at the basal surface of mouse podocytes and colocalizes with nephrin, and genetic interaction study reveals that loss of Robo2 alleviates the abnormal podocyte structural phenotype in nephrine null mice.
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