A comprehensive overview on alkaline phosphatase targeting and reporting assays

Recent Development in Synthesis of Carbon Dots from Natural Resources and Their Applications in Biomedicine and Multi-Sensing Platform

Alkaline phosphatase (ALP), an important enzyme in living organisms, plays significant roles in the hydrolysis of phosphate groups from nucleic acids, proteins, and other substrates. Abnormal level of ALP in serum is related to a variety of diseases. Low expression of ALP can cause blood diseases, such as anemia and leukemia, while over-expression of ALP can lead to disorders in liver, prostate, endocrine system, and bone tissues. Therefore, to monitor the ALP level in physiological and pathological events, it is in urgent need to develop a rapid, accurate, sensitive, and non-invasive approach, which can also be of great significance for the improvement of corresponding clinical agents. With the development of fluorescent probes, many advantages of fluorescent probes for ALP detection, such as simple operation, non-invasive, real-time imaging, economy, fast response, and so on, have been gradually highlighted. In this review, we enumerated almost all the ALP fluorescent probes from 2009 to now and summarized their respective characteristics, in order to provide a unified platform for their standardized evaluation. Meanwhile, we tried to systematically review the research progress of ALP fluorescent probes, including both small-molecule and nanoscale ones. Logically, we focused on the structures, reaction mechanisms, and biological applications of ALP fluorescent probes. In addition, the prospects of ALP in the near future have also been foreseen. We hope that this review will be helpful for the investigators who are interested in ALP-associated biological procedures, and even in the regulation of more extensive enzyme levels.

Fluorescent probes for the detection of alkaline phosphatase in biological systems: Recent advances and future prospects

With the acceleration of industrial development, the demand for energy is also increasing. People are now facing the main problems of energy crisis and environmental pollution. Thermoelectric (TE) technology is regarded as an environmentally friendly technology. Thermoelectric applications have become more and more diversified basing the development of thermoelectric technology. This paper mainly summarizes the applications of thermoelectric technology, providing a comprehensive review of three aspects: cooling/heating, power generation, and heat flux sensor. Thermoelectric coolers (TECs) can be used to heat or cool objects by using electricity to achieve precise temperature control. Conversely, using thermoelectric generators (TEGs) allows for capturing heat and convert it into electricity. This paper introduces the applications of TEC in air conditioning, electronic cooling and thermoelectric heat pumps, and its precise temperature control ability being used in new fields. The applications of TEG in automotive engines, solar energy and wearable devices are also described. This paper also presents the thermoelectric applications for heat flux sensor. However, the main challenges lying behind thermoelectric applications are the limitation of thermoelectric materials and the system's inefficiency. Integrating temperature control, power generation and heat flux sensor for application, could improve the overall efficiency of the system and maximize energy utilization. The major objective of this paper is to provide an overview of thermoelectric applications and to explore their deeper integrated use. 

Recent progress of thermoelectric applications for cooling/heating, power generation, heat flux sensor and potential prospect of their integrated applications

Recent progress of fluorescent probes for the detection of alkaline phosphatase (ALP): A review

Recent advances in modeling and simulation of thermoelectric power generation

Yttrium vanadates based ratiometric fluorescence probe for alkaline phosphatase activity sensing

Silicate-modified silicon for advanced lithium-ion battery anode materials

Regulating Incompatible Interfaces and Electron/Ion Transport in Lithium Metal Solid State Batteries.

Hydrogen Evolution Inhibition via Dual Functional Electrolyte Additive to Achieve Highly Stable Aqueous Fe Ion Battery

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