The invention discloses a PLGA (poly(lactic-co-glycolic acid) fiber-microsphere dual-drug-loaded composite scaffold and a preparation method of the PLGA fiber-microsphere dual-drug-loaded composite scaffold and aims to solve the technical problem of complexity of a conventional preparation method of the PLGA fiber-microsphere dual-drug-loaded composite scaffold. The technical scheme comprises steps as follows: an electrostatic spinning liquid containing statin drugs is prepared from PLGA fibers and the statin drugs, a homogeneous electronic injection solution is prepared from the PLGA fibers and bioactive factors in a mass ratio being (20-600,000):1, finally, the prepared electrostatic spinning liquid and the electronic injection solution are subjected to electrospinning and electronic injection simultaneously, collected scaffold materials are placed in a vacuum drying oven to be dried for 24-48 h, and the PLGA fiber-microsphere composite scaffold material loaded with the station drugs and the bioactive factors is obtained. With the adoption of an electronic injection method of an emulsion, a water-in-oil emulsion is formed, inactivation caused by direct contact of the drugs and an organic solvent is avoided, and the method is simple. Meanwhile, a surfactant and an emulsifier are not used in the preparation process, so that the bio-safety is higher.

PLGA (poly(lactic-co-glycolic acid) fiber-microsphere dual-drug-loaded composite scaffold and preparation method of PLGA fiber-microsphere dual-drug-loaded composite scaffold

The invention relates to a method for preparing a pravastatin-loading vascular tissue engineering scaffold material by electrospinning The method comprises: (1) preparing a polyhydroxyalkanoate solution; (2) preparing a pravastatin sodium solution; 3) preparing an electrospinning solution; and (4) electrospinning to obtain a vascular tissue engineering scaffold material According to the presentinvention, the hydrophilic pravastatin sodium is loaded into the hydrophobic polyhydroxyalkanoate matrix, such that the prepared vascular tissue engineering scaffold material can achieve the long-acting release of pravastatin

Method for preparing pravastatin-loading vascular tissue engineering scaffold material by electrospinning

The invention discloses a preparation method for a lovastatin-containing tissue engineering scaffold, and relates to the field of tissue engineering. The method comprises: together dissolving lovastatin and a high-molecule material in a volatilizable solvent, so as to prepare a homogenous solution, and employing a high-voltage static spinning method to perform spinning, collection and drying, so as to obtain the lovastatin-containing tissue engineering scaffold. The preparation method is simple in operation, low in cost, friendly to environment and suitable for industrialized production. The prepared lovastatin-containing tissue engineering scaffold is controllable in composition fiber diameter and controllable in lovastatin carrying capacity.

Preparation method for lovastatin-containing tissue engineering scaffold

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Preparation method for lovastatin-containing tissue engineering scaffold