Xiya Li
6 Papers
Xiya Li is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 4 publications.
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Papers
Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells
Qi Zheng,Yonggang Zou,Peng Teng,Zhenghua Chen,Yuefeng Wu,Xiaoyi Dai,Xiya Li,Zonghao Hu,Shengjun Wu,Yanhua Xu,Weiguo Zou,Hai Song,Liang Ma +12 more
TL;DR: The activation of PIEZO1 upregulates the expression of KLF2/4 in endothelial cells and provides the molecular insight into how endothelium cells sense and convert mechanical stimuli into a biological response to promote KLF 2/4 expression for the maintenance of endothelial function and homeostasis.
Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma
Xiya Li,Ji Chuan Wu,Pingfan Liu,Zi-juan Li,Yong Wang,Bing Chen,Cheng Long Hu,M. Fei,Peng Yu,Y. Jiang,Chun Hui Xu,Binhe Chang,Xin-Chi Chen,Li Juan Zong,Jia Ying Zhang,Ying Fang,Xiao-Jian Sun,Kai Xue,Li Wang,Shu Bei Chen,Shi-Yu Jiang,Ai-Ling Gui,Ling Yang,Juan J Gu,Bo Yu,Qunling Zhang,Lan Wang +26 more
TL;DR: Zhang et al. as discussed by the authors found that ubiquitin-specific protease 1 (USP1) is highly expressed in DLBCL patients, and high expression of USP1 predicts poor prognosis.
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SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis.
Peng-Cheng Yu,Dan Hou,Binhe Chang,Na Liu,Chun Hui Xu,Xin-Chi Chen,Cheng Long Hu,Ting Liu,Xiaoning Wang,Qunling Zhang,Ping Liu,Yilun Jiang,Ming Fei,Li Juan Zong,Jia Ying Zhang,Hui Liu,Bingyi Chen,Shu Bei Chen,Yong Wang,Zi-Juan Li,Xiya Li,Chu-Han Deng,Muying Zhao,Shiyu Jiang,Roujia Wang,Jia-Cheng Jin,Shaoxin Yang,Kai Xue,Jun Shi,Chun-Kang Chang,Shuhong Shen,Zhikai Wang,Peng-Cheng He,Zhu Chen,Sai-Juan Chen,Xiao-Jian Sun,Lan Wang +36 more
TL;DR: SMARCA5 reprograms AKR1B1-mediated fructose metabolism, promoting leukemogenesis by altering chromatin accessibility and transcriptional activation of AKR1B1, a key factor associated with poor prognosis and therapeutic resistance in leukemia patients.
4
ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
Jia-Cheng Jin,Bing-Yi Chen,Chu-Han Deng,Jia-Nan Chen,Feng Xu,Ying Tao,Cheng Long Hu,Chun Hui Xu,Binhe Chang,Yong Wang,Ming Fei,Ping Liu,Peng-Cheng Yu,Zi-Juan Li,Xiya Li,Shu Bei Chen,Y. Jiang,Xin-Chi Chen,Li Juan Zong,Jia Ying Zhang,Yi-Yi Ren,Fan-Huan Xu,Qi Liu,Xin-Hui Huang,Juan Guo,Qi He,Lu-Xi Song,Li-yu Zhou,Ji-ying Su,Chao Xiao,Yu-Mei Zhang,Meng Yan,Zhen Zhang,Dong Wu,Chun-Kang Chang,Xiao Li,Lan Wang,Lingyun Wu +37 more
TL;DR: It is reported that ROBO1 deficiency confers MDS-like disease with anemia and multilineage dysplasia in mice and predicts poor prognosis in patients with MDS, and implicates the essential role ofROBO1 in maintaining HSPC homeostasis and erythropoiesis via CDC42.
The cell non-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
M. Fei,Yong Wang,Binhe Chang,Kai Xue,Fangyi Dong,Dan Huang,Xiya Li,Zirui Li,Cheng Long Hu,Pingfan Liu,Ji Chuan Wu,Peng Yu,M. Hong,Shu Bei Chen,Chun Hui Xu,Bing Chen,Y. Jiang,Na Liu,Chong Zhao,J. Jin,Dan Hou,Xin-Chi Chen,Yinghui Ren,Chu-Han Deng,Jia Ying Zhang,Li Juan Zong,Fei Fei Gao,Hui Liu,Qun Zhang,Lingyun Wu,Jinsong Yan,Shuhong Shen,Chunkang Chang,Xiao-Jian Sun,Lan Wang +34 more
TL;DR: In this article , the role of DNA binding 1 (ID1), a key transcriptional regulator in leukemia stem cells (LSC), has been investigated in AML-BMM.