Xinxian Deng
University of Washington
47 Papers
22 Citations
Xinxian Deng is an academic researcher from University of Washington. The author has contributed to research in topics: X chromosome & X-inactivation. The author has an hindex of 16, co-authored 35 publications.
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Papers
Massively multiplex single-cell Hi-C
Vijay Ramani,Xinxian Deng,Ruolan Qiu,Kevin L. Gunderson,Frank J. Steemers,Christine M. Disteche,William Stafford Noble,Zhijun Duan,Jay Shendure,Jay Shendure +9 more
TL;DR: This proof of concept method uses sciHi-C data to separate cells by karyotypic and cell-cycle state differences and identify cell-to-cell heterogeneity in mammalian chromosomal conformation.
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Massively multiplex single-cell Hi-C
Vijay Ramani,Xinxian Deng,Kevin L. Gunderson,Frank J. Steemers,Christine M. Disteche,William Stafford Noble,Zhijun Duan,Jay Shendure +7 more
TL;DR: The utility of single-cell Hi-C data in separating different cell types, identify previously uncharacterized cell-to-cell heterogeneity in the conformational properties of mammalian chromosomes, and demonstrate that combinatorial indexing is a generalizable molecular strategy for single- cell genomics are demonstrated.
315
Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster
Xinxian Deng,Joseph B. Hiatt,Di Kim Nguyen,Sevinc Ercan,David Sturgill,LaDeana W. Hillier,Felix Schlesinger,Carrie A. Davis,Valerie Reinke,Thomas R. Gingeras,Jay Shendure,Robert H. Waterston,Brian Oliver,Jason D. Lieb,Christine M. Disteche +14 more
TL;DR: These analyses, which take into account the skewed gene content of the X chromosome, support the hypothesis of upregulation of expressed X-linked genes to balance expression of the genome.
X chromosome regulation: diverse patterns in development, tissues and disease
TL;DR: The complexity and diversity of X dosage regulation affect the severity of diseases caused by X-linked mutations.
Escape from X inactivation varies in mouse tissues.
Joel B. Berletch,Wenxiu Ma,Fan Yang,Jay Shendure,William Stafford Noble,Christine M. Disteche,Xinxian Deng +6 more
TL;DR: Using a binomial model to assess allelic expression, a continuum between complete silencing and expression from the inactive X (Xi) is demonstrated, and common escape genes and genes with significant differences in XCI status between tissues were identified.