47 Papers
62 Citations
Xingjun Guo is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Pancreatic cancer & Medicine. The author has an hindex of 20, co-authored 41 publications.
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Papers
Upregulation of METTL14 mediates the elevation of PERP mRNA N 6 adenosine methylation promoting the growth and metastasis of pancreatic cancer
Min Wang,Jun Liu,Yan Zhao,Ruizhi He,Xiao-Dong Xu,Xingjun Guo,Xu Li,Simiao Xu,Ji Miao,Jianpin Guo,Jianpin Guo,Hang Zhang,Jun Gong,Feng Zhu,Rui Tian,Chengjian Shi,Feng Peng,Yechen Feng,Shuo Yu,Yu Xie,Jianxin Jiang,Min Li,Wenyi Wei,Chuan He,Renyi Qin +24 more
TL;DR: The data suggest that the upregulation of METTL14 leads to the decrease of PERP levels via m6A modification, promoting the growth and metastasis of pancreatic cancer; thereforeMETTL14 is a potential therapeutic target for its treatment.
Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells.
Xu Li,Feng Zhu,Jianxin Jiang,Chengyi Sun,Xin Wang,Ming Shen,Rui Tian,Chengjian Shi,Meng Xu,Feng Peng,Xingjun Guo,Min Wang,Renyi Qin +12 more
TL;DR: It is found that WA enhanced oxaliplatin-induced growth suppression and apoptosis in PC cells dramatically through a mechanism involving mitochondrial dysfunction and inactivation of the PI3K/AKT pathway, which supports the notion that combination treatment with oxali Platin and WA could facilitate development of an effective strategy for PC treatment.
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KIF15 promotes pancreatic cancer proliferation via the MEK–ERK signalling pathway
TL;DR: KIF15 was upregulated in human pancreatic cancer tissues, and higher KIF15 expression levels correlated with shorter patient survival times, broadening the understanding of Kif15 function in tumorigenesis.
Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells
Xu Li,Feng Zhu,Jianxin Jiang,Chengyi Sun,Qing Zhong,Ming Shen,Xin Wang,Rui Tian,Chengjian Shi,Meng Xu,Feng Peng,Xingjun Guo,Jun Hu,Dawei Ye,Min Wang,Renyi Qin +15 more
TL;DR: It is demonstrated that withaferin-A (WA), the biologically active withanolide extracted from Withania somnifera, significantly increased autophagosomes, but blocked the degradation of autophagic cargo by inhibiting SNARE-mediated fusion of autophile cargo in human pancreatic cancer (PC) cells.
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MicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1
Chao Yu,Min Wang,Zhipeng Li,Jie Xiao,Feng Peng,Xingjun Guo,Deng Yazhu,Jianxin Jiang,Chengyi Sun +8 more
TL;DR: It is found that over-expression of miR-138-5p may serve as a novel approach for the treatment of patients with pancreatic cancer and that silencing of FOXC1 by siRNA had an inhibitory effect on pancreaticcancer cell growth.