30 Papers
35 Citations
Xing Chen is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 19 publications. Previous affiliations of Xing Chen include Cleveland Clinic.
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Papers
The role of interleukin-17 in tumor development and progression
TL;DR: This review discusses the growing literature on the pathogenic role of IL-17 in cancer, focusing on recent studies that placeIL-17 as a nexus linking inflammation, tissue repair, and cancer.
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Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
Yun Liao,Yun Liao,Junjie Zhao,Katarzyna Bulek,Katarzyna Bulek,Fangqiang Tang,Xing Chen,Gang Cai,Shang Jia,Paul L. Fox,Emina Huang,Theresa T. Pizarro,Matthew F. Kalady,Mark W. Jackson,Shideng Bao,Ganes C. Sen,George R. Stark,Christopher J. Chang,Xiaoxia Li +18 more
TL;DR: It is shown that STEAP4 is induced by IL17, which is increased in inflamed tissues, consequently the increased copper levels activate NFκB signalling and suppression of apoptosis, and copper is known to be enhanced in cancer tissues.
Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis.
Katarzyna Bulek,Katarzyna Bulek,Junjie Zhao,Yun Liao,Nitish Rana,Daniele Corridoni,Agne Antanaviciute,Xing Chen,Han Wang,Wen Qian,William Miller-Little,Shadi Swaidani,Fangqiang Tang,Belinda Willard,Keith R. McCrae,Zizhen Kang,George R. Dubyak,Fabio Cominelli,Fabio Cominelli,Alison Simmons,Theresa T. Pizarro,Xiaoxia Li +21 more
TL;DR: Increased expression of epithelial-derived GSDMD is observed both in patients with inflammatory bowel disease (IBD) and those with experimental colitis, implicating G SDMD-mediated release of IL-1β sEVs in the pathogenesis of intestinal inflammation, such as that observed in IBD.
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation
Cun-Jin Zhang,Meiling Jiang,Meiling Jiang,Meiling Jiang,Hao Zhou,Weiwei Liu,Chenhui Wang,Chenhui Wang,Zizhen Kang,Bing Han,Quanri Zhang,Xing Chen,Jianxin Xiao,Amanda Fisher,William J. Kaiser,Masanori A. Murayama,Yoichiro Iwakura,Ji Gao,Julie Carman,Ashok Dongre,George R. Dubyak,Derek W. Abbott,Fu-Dong Shi,Richard M. Ransohoff,Xiaoxia Li +24 more
TL;DR: Microglia-derived IL-1&bgr; via noncanonical caspase-8–dependent inflammasome is necessary for microglia to exert their pathogenic role during CNS inflammation, which is suggested to include T cell expansion and neutrophil recruitment during EAE pathogenesis.
The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo
Caini Liu,Liang Zhu,Liang Zhu,Koichi Fukuda,Suidong Ouyang,Xing Chen,Chenhui Wang,Chenhui Wang,Cun Jin Zhang,Cun Jin Zhang,Bradley N. Martin,Chunfang Gu,Luke Qin,Rachakonda Suguna,Mark A. Aronica,Jun Qin,Jun Qin,Xiaoxia Li +17 more
TL;DR: The findings uncover a previously uncharacterized molecular mechanism of action of cyanidin, which may inform its further development into an effective small-molecule drug for the treatment of IL-17A–dependent inflammatory diseases and cancer.