Xin-Yuan Fu
National University of Singapore
123 Papers
839 Citations
Xin-Yuan Fu is an academic researcher from National University of Singapore. The author has contributed to research in topics: STAT3 & STAT protein. The author has an hindex of 53, co-authored 122 publications. Previous affiliations of Xin-Yuan Fu include Sichuan University & Southern University of Science and Technology.
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Papers
Function of Mitochondrial Stat3 in Cellular Respiration
Joanna Wegrzyn,Ramesh Potla,Yong Joon Chwae,Naresh Babu V. Sepuri,Qifang Zhang,Thomas Koeck,Marta Derecka,Marta Derecka,Karol Szczepanek,Karol Szczepanek,Magdalena Szelag,Magdalena Szelag,Agnieszka Gornicka,Agnieszka Gornicka,Akira Moh,Shadi Moghaddas,Qun Chen,Santha Bobbili,Joanna Cichy,Jozef Dulak,Darren P. Baker,Alan Wolfman,Dennis J. Stuehr,Dennis J. Stuehr,Medhat O. Hassan,Xin-Yuan Fu,Narayan G. Avadhani,Jennifer I. Drake,Paul Fawcett,Edward J. Lesnefsky,Edward J. Lesnefsky,Andrew C. Larner +31 more
TL;DR: Data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.
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Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1
TL;DR: Signal transducers and activators of transcription (STAT) proteins can be conditionally activated in response to epidermal growth factor (EGF) and interferon (IFN)-gamma as mentioned in this paper.
854
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
TL;DR: It is suggested that proteins encoded by this gene family serve the function of interpreting the fact that a cell surface receptor has bound its ligand so that specific signal transduction to the nucleus can occur.
556
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.
TL;DR: It is shown that activation of the STAT signaling pathway can induce apoptosis through the induction of ICE gene expression, and studies from ICE-deficient cells indicated thatICE gene expression was necessary for IFN-gamma-induced apoptosis.
556
ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.
TL;DR: The multisubunit structure of ISGF3 most likely reflects its participation in receiving a ligand-dependent signal, translocating to the nucleus, and binding to DNA to activate transcription.
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