Xiaoyan Qiu
Peking University
62 Papers
287 Citations
Xiaoyan Qiu is an academic researcher from Peking University. The author has contributed to research in topics: Antibody & Biology. The author has an hindex of 21, co-authored 60 publications. Previous affiliations of Xiaoyan Qiu include University of Texas MD Anderson Cancer Center & Chinese Ministry of Health.
Chat about Author
Papers
•Journal Article
Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells.
Xiaoyan Qiu,Xiaohui Zhu,Liang Zhang,Yuntao Mao,Jian Zhang,Peng Hao,Guohui Li,Peng Lv,Zhixin Li,Xin Sun,Lemeng Wu,Jie Zheng,Yu-qing Deng,Chunmei Hou,Peixian Tang,Shuren Zhang,Youhui Zhang +16 more
TL;DR: It is demonstrated that human cancers of epithelial origin, including carcinomas of breast, colon, liver, lung, established epithelial cancer lines, as well as some normal lung tissues, also produce IgG in both cytoplasmic and secreted forms, and a role of tumor-derived IgG as growth factor for epithelial cancers is supported.
247
Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis
Fanlei Hu,Rong Mu,Jiaxin Zhu,Lianjie Shi,Yingni Li,Xu Liu,Wenwei Shao,Gui-ye Li,Minghui Li,Yin Su,Philip L. Cohen,Xiaoyan Qiu,Zhanguo Li +12 more
TL;DR: The findings suggest that hypoxia and HIF-1α may function in conjunction with TLR-stimulated innate immune responses to drive inflammation in RA and this pathway may serve as a therapeutic target for the disease.
116
Immunoglobulin Gene Transcripts Have Distinct VHDJH Recombination Characteristics in Human Epithelial Cancer Cells
Jie Zheng,Jing Huang,Yuntao Mao,Shiqing Liu,Xin Sun,Xiaohui Zhu,Teng Ma,Li Zhang,Jiafu Ji,Youhui Zhang,Cheng Cameron Yin,Xiaoyan Qiu +11 more
TL;DR: It was shown that the mechanism of hypermutation was different from antigen selection in B-cell-derived VHγDJHγsequences, and suggested that cancer-derived Ig genes have a distinct repertoire that may have implications for their role in carcinogenesis.
96
Hypoxia-inducible factor-1α perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis
Fanlei Hu,H Liu,Liling Xu,Yingni Li,Xu Liu,Lianjie Shi,Yin Su,Xiaoyan Qiu,Xia Zhang,Yuqin Yang,Jian Zhang,Zhanguo Li +11 more
TL;DR: It is suggested that HIF‐1α perpetuates the interactions between RASFs and T cells and B cells to induce inflammatory cytokine and autoantibody production, thus exacerbating the severity of RA.
78
Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse testis and epididymis
TL;DR: The expression of Ig in normal adult mouse testis and epididymis was detected and rearranged Ig γ chain and κ chain transcripts were expressed in testicular spermatogenic cells and epidIDymal epithelial cells.
69