Xiaolin Wan
National Institutes of Health
24 Papers
385 Citations
Xiaolin Wan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Rhabdomyosarcoma & PI3K/AKT/mTOR pathway. The author has an hindex of 15, co-authored 20 publications. Previous affiliations of Xiaolin Wan include University of Oklahoma Health Sciences Center.
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Papers
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis.
Chand Khanna,Xiaolin Wan,Seuli Bose,Ryan D. Cassaday,Osarenoma Olomu,Arnulfo Mendoza,Choh Yeung,Richard Gorlick,Stephen M. Hewitt,Lee J. Helman +9 more
TL;DR: A significant association between high ezrin expression and poor outcome in pediatric osteosarcoma patients is found and Ezrin-mediated early metastatic survival was partially dependent on activation of MAPK, but not AKT.
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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.
TL;DR: Combining an mTOR inhibitor and an IGF-1R antibody/inhibitor may be an appropriate strategy to enhance mTOR-targeted anticancer therapy.
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The Biology Behind mTOR Inhibition in Sarcoma
Xiaolin Wan,Lee J. Helman +1 more
TL;DR: For the targeted treatment of sarcomas, AP23573 has shown promising clinical efficacy and low toxicity profiles in patients, and further studies should define the optimal dose/schedule, patient selection, and combination strategies with other biological agents, especially those targeting signaling pathways crucial for cell survival.
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Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells.
Xiaolin Wan,Lee J. Helman +1 more
TL;DR: Ser473 may be a key target residue for PTEN to modulate the effects of IGF-II on activating the PI3K/Akt pathway in RMS cells, and transfection of wild-type PTEN into RMS and mouse myoblast C2C12 cells resulted in reduced Akt phosphorylation on Ser473, but not on Thr308.
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Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin.
Xiaolin Wan,Su Young Kim,Lillian M. Guenther,Arnulfo Mendoza,Joseph Briggs,Choh Yeung,Duane Currier,Hua Zhang,Crystal L. Mackall,Wan-Ju Li,Rocky S. Tuan,Andrea T. Deyrup,Chand Khanna,Lee J. Helman +13 more
TL;DR: This study shows that β4 integrin is highly expressed in human osteosarcoma cell lines and tumor samples, and identifies a previously uncharacterized interaction between β4 Integrin and ezrin, a membrane-cytoskeletal linker protein that is implicated in the metastatic behavior of osteosARcoma.
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