Xiaodan Li
Nankai University
15 Papers
12 Citations
Xiaodan Li is an academic researcher from Nankai University. The author has contributed to research in topics: Diabetes mellitus & Trehalose. The author has an hindex of 6, co-authored 15 publications.
Chat about Author
Papers
Effect of Vanadyl Rosiglitazone, a New Insulin-Mimetic Vanadium Complexes, on Glucose Homeostasis of Diabetic Mice.
Pingzhe Jiang,Dong Zhen,Baicheng Ma,Zaizhong Ni,Huikun Duan,Xiaodan Li,Bin Wang,Xiaofeng Ma,Qian Wei,Xiangzhen Ji,Minggang Li +10 more
TL;DR: The study indicated that vanadyl rosiglitazone presents insulin-mimetic activities, and it will be a good potential candidate for the development of a new type of oral drug for type 2 diabetes.
29
Liver histone H3 methylation and acetylation may associate with type 2 diabetes development.
Peipei Tu,Xiaodan Li,Baicheng Ma,Huikun Duan,Yaofang Zhang,Ri Wu,Zaizhong Ni,Pingzhe Jiang,Haisong Wang,Miao Li,Jian-Hong Zhu,Minggang Li +11 more
TL;DR: The data indicated that the progression of type 2 diabetes mellitus (T2D) is associated with global liver histone H3K9 and H2K23 acetylation, H3 k4 monomethylation and H3k9 dimethylation, which may represent a novel strategy to prevent T2D.
27
Acute toxicity, twenty-eight days repeated dose toxicity and genotoxicity of vanadyl trehalose in kunming mice.
Pingzhe Jiang,Zaizhong Ni,Bin Wang,Baicheng Ma,Huikun Duan,Xiaodan Li,Xiaofeng Ma,Qian Wei,Xiangzhen Ji,Qiqi Liu,Shuguang Xing,Minggang Li +11 more
TL;DR: Stomach and intestine were demonstrated to be the main target organs of vanadyl trehalose through 28 days repeated dose toxicity study and it showed particular genotoxicity through mouse bone marrow micronucleus and mouse sperm malformation assay.
13
Construction of a Fusion Peptide 5rolGLP-HV and Analysis of its Therapeutic Effect on Type 2 Diabetes Mellitus and Thrombosis in Mice.
Zaizhong Ni,Yaofang Zhang,Haisong Wang,Yiming Wei,Baicheng Ma,Junfeng Hao,Peipei Tu,Huikun Duan,Xiaodan Li,Pingzhe Jiang,Xiaofeng Ma,Bin Wang,Ri Wu,Jian-Hong Zhu,Minggang Li +14 more
TL;DR: Oral administration of 5rolGLP-HV significantly decreased the levels of blood glucose, GHbA1C, TC, and TG in diabetic mice at the time of 3 weeks compared to the saline-treated group, while the insulin level was reversed significantly.
13
Expression and purification of optimized rolGLP-1, a novel GLP-1 analog, in Escherichia coli BL21(DE3) and its good glucoregulatory effect on type 2 diabetic mice.
Baicheng Ma,Peipei Tu,Xingyu Zhao,Yaofang Zhang,Wang Yu,Chao Ma,Yanli Ji,Xiaodan Li,Syed A. Abbas,Minggang Li +9 more
TL;DR: In this paper, an optimized GLP-1(GLPO) with no redundant amino acids and purification tag was constructed by molecular cloning and site-directed mutagenesis, which was expressed efficiently in Escherichia coli BL21(DE3) with the production of 815 mg/L.
11