Wolfgang Bergmeier
University of North Carolina at Chapel Hill
165 Papers
358 Citations
Wolfgang Bergmeier is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 55, co-authored 147 publications. Previous affiliations of Wolfgang Bergmeier include Boston Children's Hospital & Thomas Jefferson University.
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Papers
A Critical Role of Platelet Adhesion in the Initiation of Atherosclerotic Lesion Formation
Steffen Massberg,Korbinian Brand,Sabine Grüner,Sharon Page,Elke Müller,Iris Müller,Wolfgang Bergmeier,Thomas Richter,Michael Lorenz,Ildiko Konrad,Bernhard Nieswandt,Meinrad Gawaz +11 more
TL;DR: It is shown in vivo that platelets adhere to the vascular endothelium of the carotid artery in ApoE − / − mice before the development of manifest atherosclerotic lesions, establishing the platelet as a major player in initiation of the atherogenetic process.
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Glycoprotein VI but not α2β1 integrin is essential for platelet interaction with collagen
Bernhard Nieswandt,Cord Brakebusch,Wolfgang Bergmeier,Valerie Schulte,Daniel Bouvard,Rabée Mokhtari-Nejad,Theo Lindhout,Johan W. M. Heemskerk,Hubert Zirngibl,Reinhard Fässler +9 more
TL;DR: It is shown that platelets lacking GPVI can not activate integrins and consequently fail to adhere to and aggregate on fibrillar as well as soluble collagen, and that GPVI plays the central role in platelet‐collagen interactions by activating different adhesive receptors, including α2β1 integrin.
The Clearance Mechanism of Chilled Blood Platelets
Karin M. Hoffmeister,Thomas W. Felbinger,Hervé Falet,Cécile V. Denis,Wolfgang Bergmeier,Tanya N. Mayadas,Ulrich H. von Andrian,Denisa D. Wagner,Thomas P. Stossel,John H. Hartwig +9 more
TL;DR: It is proposed that platelets are thermosensors, primed at peripheral sites where most injuries occurred throughout evolution, and GPIb modification might permit cold platelet storage.
456
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
Jill R. Crittenden,Jill R. Crittenden,Wolfgang Bergmeier,Yanyu Zhang,Crystal L. Piffath,Yuqiong Liang,Denisa D. Wagner,David E. Housman,Ann M. Graybiel +8 more
TL;DR: Through genetic ablation in the mouse, it is found that CalDAG-GEFI is crucial for signal integration in platelets, and results suggest that analogous signaling defects are likely to occur in the central nervous system when CalD AG- GEFI is absent or compromised in function.
415
Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice.
Bernhard Nieswandt,Wolfgang Bergmeier,Kirsten Rackebrandt,J. Engelbert Gessner,Hubert Zirngibl +4 more
TL;DR: The data strongly suggest that the identity of the target antigen recognized by antiplatelet antibodies determines the mechanisms of platelet destruction and the severity of bleeding in mice, the latter depending on previously unrecognized anti-GPIIbIIIa-specific inflammatory mechanisms.
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