William G. Cioffi
Rhode Island Hospital
20 Papers
128 Citations
William G. Cioffi is an academic researcher from Rhode Island Hospital. The author has contributed to research in topics: Medicine & Mortality rate. The author has an hindex of 20, co-authored 20 publications. Previous affiliations of William G. Cioffi include United States Department of the Army & University of Alabama.
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Papers
Testosterone Receptor Blockade After Hemorrhage in Males: Restoration of the Depressed Immune Functions and Improved Survival Following Subsequent Sepsis
Martin K. Angele,Matthias W. Wichmann,Matthias W. Wichmann,Alfred Ayala,William G. Cioffi,Irshad H. Chaudry +5 more
TL;DR: The findings that flutamide not only markedly improves the depressed immune functions but also the survival of animals after hemorrhage and the induction of sepsis suggest that the short-term administration of androgen receptor blocker in males after trauma represents a safe and novel approach for preventing immune deficiency and decreasing the mortality rate from subsequent sepsi.
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Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis
Markus W. Knöferl,Martin K. Angele,Michael D. Diodato,Martin G. Schwacha,Alfred Ayala,William G. Cioffi,Kirby I. Bland,Irshad H. Chaudry +7 more
TL;DR: It is suggested that female sex hormones play a critical role in maintaining immune responses after trauma-hemorrhage by suppressing the elaboration of tumor necrosis factor-alpha and prevent the increased lethality from subsequent sepsis.
207
Plasma cytokines following thermal injury and their relationship with patient mortality, burn size, and time postburn
Adriana C. Drost,David G. Burleson,William G. Cioffi,Bryan S. Jordan,Arthur D. Mason,Basil A. Pruitt +5 more
TL;DR: It is suggested that IL-1 beta and IL-6 may influence metabolic and immunologic responses in the first few weeks following thermal injury.
Halo vest immobilization in the elderly: a death sentence?
TL;DR: OLD patients with CSFs have higher mortality than YNG and HVI in OLD patients is associated with the worst outcomes, irrespective of injury severity, and should be considered a last resort.
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Transfer times to definitive care facilities are too long: a consequence of an immature trauma system.
TL;DR: All but the most severely injured patients spend prolonged periods of time in LOCs, and many require critical interventions upon arrival at the TC, which means trauma system planning efforts should focus on prehospital destination protocols that allow direct transport to the TC and education of caregivers inLOCs to enhance intervention skill sets and expedite transfer to definitive care.
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