15 Papers
10 Citations
Wendy Xin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Ubiquitin ligase. The author has an hindex of 7, co-authored 12 publications. Previous affiliations of Wendy Xin include National Institutes of Health & Johns Hopkins University.
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Papers
Myelin plasticity: sculpting circuits in learning and memory.
Wendy Xin,Jonah R. Chan +1 more
TL;DR: Recent work characterizing plasticity in the oligodendrocyte lineage following sensory experience and learning is summarized, the physiological and behavioural consequences of manipulating that plasticity are summarized, and the evidence for oligodendsia and myelin dysfunction in neurodevelopmental disorders with cognitive symptoms is discussed.
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Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease.
Jing-Fei Chen,Kun Liu,Bo Hu,Rong-Rong Li,Wendy Xin,Hao Chen,Fei Wang,Lin Chen,Rui-Xue Li,Shu-Yu Ren,Lan Xiao,Jonah R. Chan,Feng Mei +12 more
TL;DR: In this article, the authors characterized the dynamics of myelin generation and loss in the APP/PS1 mouse model of Alzheimer's disease and observed a dramatic increase in the rate of new myelin formation.
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Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase.
Wendy Xin,Wendy Xin,Yevgeniya A. Mironova,Hui Shen,Rosa Anna Maria Marino,Ari Waisman,Wouter H. Lamers,Dwight E. Bergles,Antonello Bonci +8 more
TL;DR: It is shown that oligodendrocytes, the myelinating glia of the central nervous system, also express high levels of GS in caudal regions like the midbrain and the spinal cord and may represent a therapeutic target for pathological conditions related to brain glutamate dysregulation.
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Validating visual evoked potentials as a preclinical, quantitative biomarker for remyelination efficacy.
Christian Cordano,Jung Hyung Sin,Garrett Timmons,Hao Yiu,Karin J. Stebbins,Caroline Guglielmetti,Andrés Cruz-Herranz,Wendy Xin,Daniel S. Lorrain,Jonah R. Chan,Ari J. Green +10 more
TL;DR: Using the capacity for therapeutic enhancement and biological loss of function it is demonstrated conclusively that VEP measures myelin status and is thereby a validated tool for preclinical verification of remyelination.
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VTA dopamine neuron plasticity - the unusual suspects.
TL;DR: The findings within the VTA are summarized as well as observations made in other brain regions that have important implications for plasticity in general and should be considered in the context of DA neuron plasticity.
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