W. C. Chan
University of Nebraska Medical Center
27 Papers
298 Citations
W. C. Chan is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Diffuse large B-cell lymphoma & Lymphoma. The author has an hindex of 17, co-authored 26 publications.
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Papers
The lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes.
Ash A. Alizadeh,Ash A. Alizadeh,Michael B. Eisen,Ruth E. Davis,Chi Ma,Hajeer Sabet,Truc Tran,John Powell,Liming Yang,Gerald E. Marti,D. T. Moore,J. R. Hudson,W. C. Chan,Timothy C. Greiner,D. D. Weisenburger,James O. Armitage,Izidore S. Lossos,Ronald Levy,David Botstein,Patrick O. Brown,Louis M. Staudt +20 more
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Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Javeed Iqbal,Can Küçük,Ronald J. deLeeuw,Gopesh Srivastava,Wayne Tam,Huimin Geng,David Klinkebiel,Judith K. Christman,K. Patel,Kajia Cao,Liyin Shen,Karen Dybkær,I. F L Tsui,Hesham H. Ali,Norio Shimizu,Wing Yan Au,Wing Lok Lam,W. C. Chan +17 more
TL;DR: A general tumor-promoting effect of genetic alterations is shown and PRDM1 is identified as the most likely target gene in del6q21 and ATG5, an essential gene for autophagy and AIM1, a gene implicated in melanoma, may also participate in the functional abnormalities.
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Clonal relationship between lymphocytic predominance Hodgkin's disease and concurrent or subsequent large-cell lymphoma of B lineage.
TL;DR: A clonospecific assay showed that the LPHD and LCL shared a common clone that was further confirmed by sequence analysis, providing genotypic evidence that, at least in some cases, the LCL represents a clonal progression of LPHD.
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Array-based DNA methylation profiling in follicular lymphoma
Ciaran O'Riain,Derville O’Shea,Youwen Yang,R. Le Dieu,John G. Gribben,Karin E. Summers,J. Yeboah-Afari,Leena Bhaw-Rosun,C. Fleischmann,Charles A. Mein,Tim Crook,Paul Smith,G. Kelly,Andreas Rosenwald,German Ott,German Ott,Elias Campo,Lisa M. Rimsza,Erlend B. Smeland,W. C. Chan,Nathalie A. Johnson,Randy D. Gascoyne,S. Reimer,Rita M. Braziel,G. W. Wright,Louis M. Staudt,T. A. Lister,Jude Fitzgibbon +27 more
TL;DR: Methylation values allowed separation of untreated FL samples from controls with one exception, based primarily on tumour-specific gains of methylation typically occurring within CpG islands, suggesting that widespread methylation represents an early event in lymphomagenesis and may not contribute substantially to transformation.
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