Víctor M. Navarro
Brigham and Women's Hospital
131 Papers
299 Citations
Víctor M. Navarro is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Kisspeptin & Neurokinin B. The author has an hindex of 52, co-authored 128 publications. Previous affiliations of Víctor M. Navarro include University of Washington & University of Chile.
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Papers
Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse
Víctor M. Navarro,Michelle L. Gottsch,Charles Chavkin,Hiroaki Okamura,Donald K. Clifton,Robert A. Steiner +5 more
TL;DR: A model whereby NKB and dynorphin act autosynaptically onkisspeptin neurons in the Arc to synchronize and shape the pulsatile secretion of kisspeptin and drive the release of GnRH from fibers in the median eminence is proposed.
759
Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat
Yoshihiro Wakabayashi,Tomoaki Nakada,Ken Murata,Satoshi Ohkura,Kazutaka Mogi,Víctor M. Navarro,Donald K. Clifton,Yuji Mori,Hiroko Tsukamura,Kei-ichiro Maeda,Robert A. Steiner,Hiroaki Okamura +11 more
TL;DR: Investigating the possible coexpression of kisspeptin, neurokinin B (NKB), and dynorphin A (Dyn) in neurons of the ARC of the goat and evaluating their potential roles in generating GnRH pulses found that all three neuropeptides are coexpressed in the same population of neurons.
587
Central precocious puberty caused by mutations in the imprinted gene MKRN3
Ana Paula Abreu,Andrew Dauber,Delanie B. Macedo,Sekoni D. Noel,Vinicius Nahime Brito,John C. Gill,Priscilla Cukier,Iain R. Thompson,Víctor M. Navarro,Priscila Gagliardi,Tânia Rodrigues,Cristiane Kochi,Carlos Alberto Longui,Dominique Beckers,Francis de Zegher,Luciana Ribeiro Montenegro,Berenice B. Mendonca,Rona S. Carroll,Joel N. Hirschhorn,Ana Claudia Latronico,Ursula B. Kaiser +20 more
TL;DR: Deficiency of MKRN3 causes central precocious puberty in humans, and all affected persons inherited the mutations from their fathers, a finding that indicates perfect segregation with the mode of inheritance expected for an imprinted gene.
Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54
Víctor M. Navarro,R. Fernández-Fernández,Juan M. Castellano,Juan Carlos Roa,A. Mayen,M. L. Barreiro,F Gaytan,Enrique Aguilar,Leonor Pinilla,Carlos Dieguez,Manuel Tena-Sempere +10 more
TL;DR: It is reported that chronic central administration of KiSS‐1 peptide to immature female rats induced the precocious activation of the gonadotrophic axis, as estimated by advanced vaginal opening, elevated uterus weight, and increased serum levels of luteinizing hormone (LH) and oestrogen.
488
Novel signals for the integration of energy balance and reproduction.
R. Fernández-Fernández,A. C. Martini,Víctor M. Navarro,Juan M. Castellano,Carlos Dieguez,Enrique Aguilar,Leonor Pinilla,Manuel Tena-Sempere +7 more
TL;DR: It is proposed that the peripheral hormones, ghrelin and PYY3-36, and the central neuropeptide, kisspeptin, are 'novel' players in the neuroendocrine networks that integrate energy balance and reproduction.
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