Varun Dewaker
13 Papers
26 Citations
Varun Dewaker is an academic researcher. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 1, co-authored 1 publications.
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Papers
In silico Analysis Metabolic Pathways for Identification of Putative Drug Targets for Staphylococcus aureus
TL;DR: An insilico comparative analysis of metabolic pathways of the host Homo sapiens and the pathogen S. aureus has found 5 unique pathways among 59 essential and 23 non homologous enzymes.
Copper-Catalyzed Oxidative [3 + 2]-Annulation of Quinoxalin-2(1H)-one with Oxime Esters toward Functionalized Pyrazolo[1,5-a]quinoxalin-4(5H)-ones as Opioid Receptor Modulators.
Anamika Yadav,Anubha Yadav,Shashank Tripathi,Varun Dewaker,Ruchir Kant,Prem N. Yadav,Ajay Kumar Srivastava +6 more
TL;DR: In this article , pyrazolo[1,5-a]quinoxalin-4(5H)-one derivatives were synthesized via copper-catalyzed oxidative [3 + 2]-annulation of quinoxalin and oxime-O-acetates.
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Instigating the In Vitro Anticancer Activity of New Pyridine-Thiazole-Based Co(III), Mn(II), and Ni(II) Complexes: Synthesis, Structure, DFT, Docking, and MD Simulation Studies
Pradip Bera,Abhishek Aher,Paula Brandão,Utsab Debnath,Varun Dewaker,Sunil Kr. Manna,Abhimanyu Jana,Chandana Pramanik,Basudev Mandal,Pulakesh Bera +9 more
TL;DR: The perchlorate salt of (4-methoxy phenyl)-2-(1-pyridine-2-yl)ethylidene)hydrazinyl)thiazole (PytH·ClO4) and its metal perchlorates derivatives have been synthesized and characterized through single X-ray crystallography and spectroscopic methods as discussed by the authors .
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C-Mannosyltransferase Is Essential for Malaria Transmission in Plasmodium berghei.
TL;DR: It is shown that C-mannosylation catalyzing enzyme C-manT plays an essential role in malaria transmission in Plasmodium berghei and knockout CmanT knockout (CmanT-) parasites showed normal ookinete formation; however, these ookinetes failed in their ability to glide.
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N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation
Utsab Debnath,Amrita Mitra,Varun Dewaker,Yenamandra S. Prabhakar,Raghu Tadala,Kiran Krishnan,P. Wagh,U. Velusamy,Chandru Subramani,Shubhra Agarwal,Sudhanshu Vrati,A. Baliyan,Anura V Kurpad,Parthasarathi Bhattacharyya,Amitava Mandal +14 more
- 06 Jan 2021
TL;DR: It is hypothesized that perturbing the functionally active conformation of spike protein through reduction of its solvent accessible disulfide bond, thereby disintegrating its structural architecture, may be a feasible strategy to prevent infection.
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