Toshiyuki Habu
Mukogawa Women's University
31 Papers
80 Citations
Toshiyuki Habu is an academic researcher from Mukogawa Women's University. The author has contributed to research in topics: Mad2 & Spindle checkpoint. The author has an hindex of 14, co-authored 25 publications. Previous affiliations of Toshiyuki Habu include Kyoto University.
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Papers
Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes SCA36, a Type of Spinocerebellar Ataxia Accompanied by Motor Neuron Involvement
Hatasu Kobayashi,Koji Abe,Tohru Matsuura,Yoshio Ikeda,Toshiaki Hitomi,Yuji Akechi,Toshiyuki Habu,Wanyang Liu,Hiroko Okuda,Akio Koizumi +9 more
TL;DR: Genetic analysis of a unique form of SCA (SCA36) that is accompanied by motor neuron involvement suggests that SCA36 is caused by hexanucleotide repeat expansions through RNA gain of function.
Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo
Hatasu Kobayashi,Yoshiko Matsuda,Toshiaki Hitomi,Hiroko Okuda,Hirotomo Shioi,Tetsuya Matsuda,Hirohiko Imai,Masakatsu Sone,Daisuke Taura,Kouji H. Harada,Toshiyuki Habu,Yasushi Takagi,Susumu Miyamoto,Akio Koizumi +13 more
TL;DR: This study suggests the importance of inflammatory signals as environmental factors and R4810K carriers for susceptibility to cerebral hypoxia and suggests a specific inhibitor of ATP binding to the first AAA+ could be a promising therapeutic candidate for MMD.
131
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
Robert S. Banh,Caterina Iorio,Richard Marcotte,Yang Xu,Yang Xu,Yang Xu,Dan Cojocari,Dan Cojocari,Anas M. Abdel Rahman,Judy Pawling,Wei Zhang,Ankit Sinha,Ankit Sinha,Christopher M. Rose,Marta Isasa,Shuang Zhang,Ronald Wu,Ronald Wu,Carl Virtanen,Toshiaki Hitomi,Toshiyuki Habu,Sachdev S. Sidhu,Akio Koizumi,Sarah E. Wilkins,Thomas Kislinger,Thomas Kislinger,Steven P. Gygi,Christopher J. Schofield,James W. Dennis,Bradly G. Wouters,Bradly G. Wouters,Benjamin G. Neel,Benjamin G. Neel +32 more
TL;DR: It is concluded that PTP1B acts via RNF213 to suppress α-KGDD activity and NMOC and is critical for survival of HER2+ BC, and possibly other malignancies, in the hypoxic tumour microenvironment.
Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients
Toshiaki Hitomi,Toshiyuki Habu,Hatasu Kobayashi,Hiroko Okuda,Kouji H. Harada,Kenji Osafune,Daisuke Taura,Masakatsu Sone,Isao Asaka,Tomonaga Ameku,Akira Watanabe,Tomoko Kasahara,Tomomi Sudo,Fumihiko Shiota,Hirokuni Hashikata,Yasushi Takagi,Daisuke Morito,Susumu Miyamoto,Kazuwa Nakao,Akio Koizumi +19 more
TL;DR: RNF213 R4810K reduced angiogenic activities of iPSECs from patients with MMD, suggesting that it is a promising in vitro model for MMD.
114
A new horizon of moyamoya disease and associated health risks explored through RNF213
Akio Koizumi,Hatasu Kobayashi,Toshiaki Hitomi,Kouji H. Harada,Toshiyuki Habu,Shohab Youssefian +5 more
TL;DR: The importance of a more updated definition for MMD, of qualified cohort studies based on genetic epidemiology and an awareness of the ethical issues associated with genetic testing of carriers are emphasized.