Toshiro Inoue
Kurume University
12 Papers
120 Citations
Toshiro Inoue is an academic researcher from Kurume University. The author has contributed to research in topics: Bile acid & Neonatal cholestasis. The author has an hindex of 7, co-authored 12 publications.
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Papers
Perinatal bile acid metabolism : analysis of urinary bile acids in pregnant women and newborns
Akihiko Kimura,M. Suzuki,T Murai,Toshiro Inoue,Hirohisa Kato,D Hori,Y Nomura,T Yoshimura,T Kurosawa,Masahiko Tohma +9 more
TL;DR: Data suggest that, during the perinatal period, the formation of polyhydroxylated and unsaturated ketonic bile acids probably represents a mechanism for the excretion of bile salts, and that the metabolism of biles acids in both the mother and the infant changes significantly after birth.
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Developmental pattern of 3-oxo-delta 4 bile acids in neonatal bile acid metabolism.
TL;DR: The presence of large amounts of urinary 3-oxo-Δ4 bile acids may indicate immaturity in the activity of hepatic 3-Oxo- Δ4-steroid 5β-reductase in the first week of postnatal life.
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Fetal Bile Acid Metabolism: Analysis of Urinary 3β-Monohydroxy-Δ5 Bile Acid in Preterm Infants
TL;DR: The high urinary concentrations of total bile acids in preterm infants may be due to an overproduction, or more likely to a low hepatic bile acid clearance, and an alternative fetal pathway, the acidic pathway, may be a major route of bile Acid biosynthesis in pre term infants.
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Urinary 7α-hydroxy-3-oxochol-4-en-24-oic and 3-oxochola-4,6-dien-24-oic acids in infants with cholestasis
Akihiko Kimura,Mikako Suzuki,Tsuyoshi Murai,Takao Kurosawa,Masahiko Tohma,Michio Sata,Toshiro Inoue,Atsuo Hoshiyama,Eisuke Nakashima,Yasuhiro Yamashita,Takuji Fujisawa,Hirohisa Kato +11 more
TL;DR: The results indicate that an increase in the 7alpha-hydroxy-3-oxo-delta4-en-24-oic acid and 3-oxochola-4,6-dien- 24- oic acid in the urine of patients with hepatobiliary disease indicates a poor prognosis.
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Diagnosis of the first Japanese patient with 3-oxo-Δ4-steroid 5β-reductase deficiency by use of immunoblot analysis
Akihiko Kimura,K. H. Kondo,K. I. Okuda,S. Higashi,Mikako Suzuki,Takao Kurosawa,M. Tohma,Toshiro Inoue,Atsushi Nishiyori,Makoto Yoshino,Hirohisa Kato,T. Setoguchi +11 more
TL;DR: It is suggested that this patient with severe neonatal cholestasis associated with hypertyrosinaemia had a secondary 5β-reductase deficiency due to severe liver damage, even though 3-oxo-Δ4 bile acids constituted more than 70% of total urinary bile acid.
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