Torsten J. Schulze
German Red Cross
25 Papers
52 Citations
Torsten J. Schulze is an academic researcher from German Red Cross. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 9, co-authored 21 publications. Previous affiliations of Torsten J. Schulze include Heidelberg University.
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Papers
Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients.
Huanhuan Jiang,Huanhuan Jiang,Huanhuan Jiang,Christoffer Gebhardt,Christoffer Gebhardt,Ludmila Umansky,Philipp Beckhove,Torsten J. Schulze,Jochen Utikal,Jochen Utikal,Viktor Umansky,Viktor Umansky +11 more
TL;DR: The data highlight a complex association between circulating inflammatory mediators, Mo‐MDSCs and the clinical outcome as well as suggest that their levels in patients with advanced melanoma are of important prognostic value allowing the identification of those with high risk of disease progression.
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CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions.
Carolin Blattner,Viktor Fleming,Rebekka Weber,Bianca S Himmelhan,Peter Altevogt,Christoffer Gebhardt,Torsten J. Schulze,Hila Razon,Elias Hawila,Gizi Wildbaum,Jochen Utikal,Nathan Karin,Viktor Umansky +12 more
TL;DR: These findings validate the importance of the CCR5/CCR5 ligand axis not only for MDSC recruitment but also for further activation of their immunosuppressive functions in the tumor microenvironment, with potentially broad therapeutic implications, given existing clinically available inhibitors of this axis.
Eosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitors
Sonja C. S. Simon,Xiaoying Hu,Jasper Panten,Mareike Grees,Simon Renders,Daniel Thomas,Rebekka Weber,Torsten J. Schulze,Jochen Utikal,Viktor Umansky +9 more
TL;DR: The level of eosinophils is suggested as a novel predictive marker for melanoma patients who may benefit from this immunotherapy by highlighting additional mechanisms of ICI effects and suggesting that clinical responses to ICI treatment were associated with an eOSinophil accumulation in the peripheral blood.
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Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment.
Tina Fuchs,Martin Hahn,Lukas Ries,Sophie Giesler,Svenja Busch,Chunlin Wang,Jian Han,Torsten J. Schulze,Kerstin Puellmann,Alexander W. Beham,Wolfgang E. Kaminski,Michael Neumaier +11 more
TL;DR: It is demonstrated that Ig expression is a defining feature of monocytes and also macrophages in the tumor microenvironment and thus reveal an as yet unrecognized modus operandi of host defense in professional phagocytes.
Ezetimibe inhibits platelet activation and uPAR expression on endothelial cells.
Tobias Becher,Torsten J. Schulze,Melanie Schmitt,Frederik Trinkmann,Ibrahim El-Battrawy,Ibrahim Akin,Thorsten Kälsch,Martin Borggrefe,Ksenija Stach +8 more
TL;DR: In this in vitro analysis, ezetimibe directly attenuates platelet activation and has significant endothelial cell mediated effects on selected markers of atherosclerosis.
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