Tony Tu
University of Chicago
5 Papers
Tony Tu is an academic researcher from University of Chicago. The author has contributed to research in topics: T cell & Cytokine. The author has an hindex of 5, co-authored 5 publications.
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Papers
Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
Youjin Lee,Sogyong L. Auh,Yugang Wang,Byron Burnette,Yang Wang,Yuru Meng,Michael A. Beckett,Rohit Sharma,Robert K. Chin,Tony Tu,Ralph R. Weichselbaum,Yang Xin Fu +11 more
TL;DR: It is reported that reduction of tumor burden after ablative RT depends largely on T-cell responses, and the need for new strategies that not only reduce tumor burden but also enhance the role of antitumor immunity is emphasized.
1.3K
Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection
Xiaohuan Guo,Ju Qiu,Tony Tu,Xuanming Yang,Liufu Deng,Robert A. Anders,Liang Zhou,Yang Xin Fu +7 more
TL;DR: Cancer therapies that utilize STAT3 inhibitors increase the risk for pathogen-mediated diarrhea through direct suppression of IL-22 from gut ILCs through directly binding to the Il22 locus.
241
CD160 is essential for NK-mediated IFN-γ production
Tony Tu,Nicholas K. Brown,Tae Jin Kim,Tae Jin Kim,Joanna Wroblewska,Xuanming Yang,Xiaohuan Guo,Seoyun Hyunji Lee,Seoyun Hyunji Lee,Vinay Kumar,Kyung Mi Lee,Kyung Mi Lee,Kyung Mi Lee,Yang Xin Fu +13 more
TL;DR: A novel CD160-deficient mouse is generated and impaired NK cell–mediated tumor elimination and IFN-γ production is shown and CD160+ NK cells are functionally distinct in secretion of IFn-γ from their CD160− NK cell counterparts.
110
Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium
David C. Binder,Ainhoa Arina,Frank Wen,Tony Tu,Ming Zhao,Robert M. Hoffman,Derek A. Wainwright,Hans Schreiber +7 more
TL;DR: It is shown that live intravenously injected or heat-killed intratumorally injected Salmonella typhimurium synergize with adoptive T cell therapy to eradicate tumors.
A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α+ DCs to Promote Long-Term T Cell Responses
Xuanming Yang,Xunmin Zhang,Xunmin Zhang,Yonglian Sun,Tony Tu,May Lynne Fu,Mendy Miller,Yang Xin Fu +7 more
TL;DR: This study uncovers a BTLA-mediated strategy used by the host that permits Listeria proliferation to enable increasing T cell responses for long-term protection.