Tomoyuki Mashimo
University of Texas Southwestern Medical Center
21 Papers
30 Citations
Tomoyuki Mashimo is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Metabolism & Citric acid cycle. The author has an hindex of 13, co-authored 21 publications.
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Papers
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Changho Choi,Sandeep K. Ganji,Ralph J. DeBerardinis,Kimmo J. Hatanpaa,Dinesh Rakheja,Dinesh Rakheja,Zoltan Kovacs,Xiao Li Yang,Tomoyuki Mashimo,Jack M Raisanen,Isaac Marin-Valencia,Juan M. Pascual,Christopher J. Madden,Bruce E. Mickey,Craig R. Malloy,Robert Bachoo,Elizabeth A. Maher +16 more
TL;DR: In this article, a non-invasive detection of 2-hydroxyglutarate (2HG) by proton magnetic resonance spectroscopy (MRS) was reported.
Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
Tomoyuki Mashimo,Kumar Pichumani,Vamsidhara Vemireddy,Kimmo J. Hatanpaa,Dinesh K. Singh,Shyam Sirasanagandla,Suraj Nannepaga,Sara Grazia Maria Piccirillo,Zoltan Kovacs,Chan Foong,Zhiguang Huang,Samuel L. Barnett,Bruce E. Mickey,Ralph J. DeBerardinis,Benjamin P. Tu,Elizabeth A. Maher,Robert Bachoo +16 more
TL;DR: The data demonstrate a strikingly common metabolic phenotype in diverse brain tumors that includes the ability to oxidize acetate in the citric acid cycle, which may be important for meeting the high biosynthetic and bioenergetic demands of malignant growth.
729
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.
Isaac Marin-Valencia,Chendong Yang,Tomoyuki Mashimo,Steve K. Cho,Hyeon-Man Baek,Xiao Li Yang,Kartik N. Rajagopalan,Melissa Maddie,Vamsidhara Vemireddy,Zhenze Zhao,Ling Cai,Levi B. Good,Benjamin P. Tu,Kimmo J. Hatanpaa,Bruce E. Mickey,José M. Matés,Juan M. Pascual,Elizabeth A. Maher,Craig R. Malloy,Craig R. Malloy,Ralph J. DeBerardinis,Robert Bachoo +21 more
TL;DR: GBM cells utilize mitochondrial glucose oxidation during aggressive tumor growth in vivo, and many of these same activities were conserved in cells cultured ex vivo from the tumors.
520
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons.
TL;DR: In mammalian brain, only synaptotagmin-1, -2, and -9 function as Ca(2+) sensors for fast release, and that these synaptoagmins are differentially expressed to confer distinct release properties onto synapses formed by defined subsets of neurons.
349
Metabolism of [U‐13C]glucose in human brain tumors in vivo
Elizabeth A. Maher,Isaac Marin-Valencia,Robert Bachoo,Tomoyuki Mashimo,Jack M Raisanen,Kimmo J. Hatanpaa,Ashish Jindal,F. Mark H Jeffrey,Changho Choi,Christopher J. Madden,Dana Mathews,Juan M. Pascual,Bruce E. Mickey,Craig R. Malloy,Craig R. Malloy,Ralph J. DeBerardinis +15 more
TL;DR: A convenient approach is illustrated that capitalizes on the high information content of 13C NMR spectroscopy and enables the analysis of intermediary metabolism in diverse cancers growing in their native microenvironment.