Thomas W. Spahn
University of Münster
19 Papers
122 Citations
Thomas W. Spahn is an academic researcher from University of Münster. The author has contributed to research in topics: Lymphotoxin & Lymphotoxin alpha. The author has an hindex of 13, co-authored 19 publications. Previous affiliations of Thomas W. Spahn include Brigham and Women's Hospital.
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Papers
Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches.
Thomas W. Spahn,Adriano Fontana,Ana Maria Caetano Faria,Anthony J. Slavin,Hans-Pietro Eugster,Xingmin Zhang,Pandelakis A. Koni,Nancy H. Ruddle,Richard A. Flavell,Paul D. Rennert,Howard L. Weiner +10 more
TL;DR: The results demonstrate that PP are not an absolute requirement for the induction of either high‐ or low‐dose oral tolerance, although oral tolerance could not be induced in animals devoid of both PP and MLN.
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Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-β/interleukin-10 and suppression of experimental autoimmune encephalomyelitis
Ana Maria Caetano Faria,Ruth Maron,Sabine Madsen Ficker,Anthony J. Slavin,Thomas W. Spahn,Howard L. Weiner +5 more
TL;DR: It is demonstrated that continuous feeding of antigen in the drinking water, as compared to a single feeding or feeding once per day over several days enhances suppression to both Th1 and Th2 type responses in B6D2F1 and BALB/c mice.
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Induction of Colitis in Mice Deficient of Peyer's Patches and Mesenteric Lymph Nodes Is Associated with Increased Disease Severity and Formation of Colonic Lymphoid Patches
Thomas W. Spahn,Hermann Herbst,Paul D. Rennert,Norbert Lügering,Christian Maaser,Mathias Kraft,Adriano Fontana,Howard L. Weiner,Wolfram Domschke,Torsten Kucharzik +9 more
TL;DR: More severe DSS-induced colitis correlates with the loss of the mesenteric lymph nodes, however, neither the absence of Peyer's patches nor the presence of colonic lymphoid patches were correlated with increased disease severity.
79
Resistance of Chemokine Receptor 6-Deficient Mice to Yersinia Enterocolitica Infection : Evidence of Defective M-Cell Formation in Vivo
S. Westphal,Andreas Lügering,Julia von Wedel,Christof von Eiff,Christian Maaser,Thomas W. Spahn,Gerhard Heusipp,M. Alexander Schmidt,Hermann Herbst,Ifor R. Williams,Wolfram Domschke,Torsten Kucharzik +11 more
TL;DR: Investigation of the course of yersiniosis in CCR6-deficient mice found these mice might be used as an in vivo model to determine M-cell function, underscoring the important role of M cells in the process of microbial uptake in physiological and pathological immune responses generated within PPs.
Expression of vascular cell adhesion molecule-1 (CD 106) in normal and neoplastic human esophageal squamous epithelium
Jan Heidemann,Christian Maaser,Andreas Lügering,Thomas W. Spahn,Klaus Peter Zimmer,Hermann Herbst,Parvaneh Rafiee,Wolfram Domschke,C. F. Krieglstein,David G. Binion,Torsten Kucharzik +10 more
TL;DR: Novel and unexpected membrane expression of VCAM-1 in the basal squamous epithelial strata of the normal human esophagus and distinct patterns of epithelial expression in esophageal pathology are reported, suggesting a previously unappreciated role for VCAM -1 in esphageal squamy epithelial homeostasis and pathology.
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