Thomas Schmehl
University of Giessen
85 Papers
360 Citations
Thomas Schmehl is an academic researcher from University of Giessen. The author has contributed to research in topics: Drug delivery & Pulmonary hypertension. The author has an hindex of 26, co-authored 85 publications.
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Papers
Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features.
Lea Ann Dailey,Thomas Schmehl,Tobias Gessler,Matthias Wittmar,Friedrich Grimminger,Werner Seeger,Thomas Kissel +6 more
TL;DR: It is concluded that the biodegradable nanoparticles contained in the suspensions did not affect the aerosol droplet size in a clinically relevant manner; however, both the nanoparticle characteristics and the technique of aerosol generation influence nanoparticle aggregation occurring during aerosolization.
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Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies.
Robert Voswinckel,Beate Enke,Frank Reichenberger,Markus G. Kohstall,Andree Kreckel,Stefanie Krick,Henning Gall,Tobias Gessler,Thomas Schmehl,Hossein Ardeschir Ghofrani,Ralph T. Schermuly,Friedrich Grimminger,Lewis J. Rubin,Werner Seeger,Horst Olschewski +14 more
TL;DR: Inhaled treprostinil exerts sustained pulmonary vasodilation with excellent tolerability at relatively low doses and may be inhaled in a few breaths.
161
Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery.
Moritz Beck-Broichsitter,Christoph Schweiger,Thomas Schmehl,Tobias Gessler,Werner Seeger,Thomas Kissel +5 more
TL;DR: The results suggest that nanospray-drying is a convenient method to prepare submicron, controlled drug delivery vehicles useful for pulmonary application potentially allowing access to alveolar tissue.
144
Pharmacodynamics and Pharmacokinetics of Inhaled Iloprost, Aerosolized by Three Different Devices, in Severe Pulmonary Hypertension
Horst Olschewski,Beate Rohde,Juürgen Behr,R Ewert,Tobias Gessler,H. Ardeschir Ghofrani,Thomas Schmehl +6 more
TL;DR: In this paper, the effects of a standardized iloprost aerosol dose (5 μg; inhaled within approximately 10 min) in 12 patients with severe pulmonary hypertension in a crossover design employing three well-characterized nebulizers.
137
Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model
Moritz Beck-Broichsitter,Julia Gauss,Claudia B. Packhaeuser,Kerstin Lahnstein,Thomas Schmehl,Werner Seeger,Thomas Kissel,Tobias Gessler +7 more
TL;DR: The data suggest that inhalative delivery of biodegradable nanoparticles may be a viable approach for pulmonary drug delivery and a targeting effect to the lung tissue is claimed.
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