Thomas L. Wallace
Baylor College of Medicine
9 Papers
130 Citations
Thomas L. Wallace is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Nystatin & Amphotericin B. The author has an hindex of 8, co-authored 9 publications.
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Papers
Comparison of In Vitro Antifungal Activities of Free and Liposome-Encapsulated Nystatin with Those of Four Amphotericin B Formulations
TL;DR: Neither formulation of nystatin was as active as amphotericin B deoxycholate (Fungizone) or amph esotericin B lipid complex (Abelcet), but both were more effective than liposomal amphoteric in B (AmBisome).
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Cytosine arabinoside kills postmitotic neurons: evidence that deoxycytidine may have a role in neuronal survival that is independent of DNA synthesis
TL;DR: 2′-deoxycytidine may have an important and previously unrecognized role in cellular function that in the case of neurons is critical for survival, as well as being an antimitotic agent for dividing cells and cytotoxic for postmitotic neurons.
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Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice
Thomas L. Wallace,Victor L. Paetznick,Paul A. Cossum,Gabriel Lopez-Berestein,John H. Rex,Elias Anaissie +5 more
TL;DR: Liposomal nystatin, at doses as low as 2 mg/kg of body weight/day, protected neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group.
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Species differences in the proportion of plasma lipoprotein lipid carried by high-density lipoproteins influence the distribution of free and liposomal nystatin in human, dog, and rat plasma.
TL;DR: The findings suggest that the distribution of NYS among plasma lipoproteins of different species is defined by the proportion of lipid carried by HDL, and this is possibly an important consideration when evaluating the pharmacokinetics, toxicities, and activities of these compounds following administration to different animal species.
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The reproductive and developmental toxicity of the antifungal drug Nyotran® (liposomal nystatin) in rats and rabbits
Jeffrey L. Larson,Thomas L. Wallace,Rochelle W. Tyl,Melissa C. Marr,Christina B. Myers,Paul A. Cossum +5 more
TL;DR: Humans tolerate higher dosages and systemic exposures of Nyotran relative to rats and rabbits and there is no margin of safety in either dosage level or systemic exposure to drug, but caution should be exercised when using this drug in females of childbearing potential.
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