Thomas Klimkait
University of Basel
252 Papers
1.9K Citations
Thomas Klimkait is an academic researcher from University of Basel. The author has contributed to research in topics: Medicine & Viral load. The author has an hindex of 50, co-authored 230 publications. Previous affiliations of Thomas Klimkait include University Hospital of Basel & National Institutes of Health.
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Papers
Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy.
Volker Nickeleit,Thomas Klimkait,Isabelle Binet,P. Dalquen,V Del Zenero,Gilbert Thiel,Michael J. Mihatsch,Hans H. Hirsch +7 more
TL;DR: Testing for BK virus DNA in plasma from renal-allograft recipients with use of the polymerase chain reaction is a sensitive and specific method for identifying viral nephropathy.
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Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein.
TL;DR: While vpu was found in significant quantities in virus-producing cells, the protein could not be detected in cell-free culture fluids and is therefore most likely not viron associated, and the data suggest that vpu has a function in the release of virus particles from infected cells.
287
Estimating the Basic Reproductive Number from Viral Sequence Data
Tanja Stadler,Roger D. Kouyos,Viktor von Wyl,Sabine Yerly,Jürg Böni,Philippe Bürgisser,Thomas Klimkait,Beda Joos,Philip Alexander Rieder,Dong Xie,Huldrych F. Günthard,Alexei J. Drummond,Sebastian Bonhoeffer +12 more
TL;DR: A new method to infer epidemiological parameters directly from viral sequence data based on phylogenetic analysis using a birth-death model rather than the commonly used coalescent as the model for the epidemiological transmission of the pathogen is provided.
European guidelines on the clinical management of HIV-1 tropism testing
Linos Vandekerckhove,Annemarie M. J. Wensing,Rolf Kaiser,Françoise Brun-Vézinet,Bonaventura Clotet,A. De Luca,A. De Luca,S. Dressler,Federico García,Anna Maria Geretti,Thomas Klimkait,Klaus Korn,Bernard Masquelier,Carlo Federico Perno,Jonathan M. Schapiro,Vincent Soriano,Anders Sönnerborg,Anne-Mieke Vandamme,Chris Verhofstede,Hauke Walter,Maurizio Zazzi,Charles A. Boucher +21 more
TL;DR: The European Consensus Group on clinical management of tropism testing was established to make recommendations to clinicians and clinical virologists recommended an enhanced sensitivity Trofile assay and V3 population genotyping are the recommended methods.
New Aza-Dipeptide Analogues as Potent and Orally Absorbed HIV-1 Protease Inhibitors: Candidates for Clinical Development
Guido Bold,Alexander Fassler,Hans-Georg Capraro,Robert Cozens,Thomas Klimkait,Janis Lazdins,Jürgen Mestan,Bernard Poncioni,Johannes Rösel,David R. Stover,Marina Tintelnot-Blomley,Figan Acemoglu,Werner Beck,Eugen Boss,Martin Eschbach,Thomas Hürlimann,Elvira Masso,Serge Roussel,Katharina Ucci-Stoll,Dominique Wyss,Marc Lang +20 more
TL;DR: The bis(L-tert-leucine) derivatives CGP 75355, CGP 73547, C GP 75136, and CGP75176 combine excellent antiviral activity with high blood concentration after oral administration and show no cross-resistance with saquinavir- resistant strains and maintain activity against indinavir-resistant ones.
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