Takahiro Ueda
Kobe University
59 Papers
396 Citations
Takahiro Ueda is an academic researcher from Kobe University. The author has contributed to research in topics: Xeroderma pigmentosum & Nucleotide excision repair. The author has an hindex of 22, co-authored 47 publications. Previous affiliations of Takahiro Ueda include National Institutes of Health & Ehime University.
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Papers
Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair
Porcia T. Bradford,Alisa M. Goldstein,Deborah Tamura,Sikandar G. Khan,Takahiro Ueda,Jennifer Boyle,Kyu-Seon Oh,Kyoko Imoto,Hiroki Inui,Shinichi Moriwaki,Steffen Emmert,Kristen M. Pike,Arati Raziuddin,Teri Plona,John J. DiGiovanna,Margaret A. Tucker,Kenneth H. Kraemer +16 more
TL;DR: A 39 year follow-up study of XP patients indicates a major role of DNA repair genes in the aetiology of skin cancer and neurologic degeneration.
•Journal Article
Transcription-coupled Nucleotide Excision Repair as a Determinant of Cisplatin Sensitivity of Human Cells
TL;DR: It is reported that TC-NER-deficient cells are hypersensitive to cisplatin irrespective of their GG-NER status, and that gene complementation with XPA and XPD increases resistance to cisPlatin.
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The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function
Sikandar G. Khan,Vanessa Muniz-Medina,Tala Shahlavi,Carl C. Baker,Hiroki Inui,Takahiro Ueda,Steffen Emmert,Thomas D. Schneider,Kenneth H. Kraemer +8 more
TL;DR: Sensitive real- time quantitative reverse transcription-polymerase chain reaction methods were developed to measure full-length XPC mRNA (the predominant form) and isoforms that skipped exons 4, 7 or 12, and found that fibroblasts homozygous for A/A had significantly higher levels of the X PC mRNA isoform that skippedExon 12, which has diminished DNA repair function and may contribute to cancer susceptibility.
Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system.
Isao Oishi,Shigeto Takeuchi,Ryuju Hashimoto,Akira Nagabukuro,Takahiro Ueda,Zhao Jun Liu,Toshihisa Hatta,Shizuo Akira,Yoichi Matsuda,Hirohei Yamamura,Hiroki Otani,Yasuhiro Minami +11 more
TL;DR: Drosophila neurospecific receptor tyrosine kinases, Dror and Dnrk, as well as Ror1 and Ror2 RTKs, isolated from human neuroblastoma, have been identified as a structurally related novel family ofRTKs (Ror‐family RTKS).
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Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients.
Steffen Emmert,Hanoch Slor,David B. Busch,Sima Batko,Roberta Bliss Albert,Donna M. Coleman,Sikandar G. Khan,Bassam Abu-Libdeh,John J. DiGiovanna,Bari B. Cunningham,Myung-Moo Lee,Jill Crollick,Hiroki Inui,Takahiro Ueda,Mohammad Hedayati,Lawrence Grossman,Tala Shahlavi,James E. Cleaver,Kenneth H. Kraemer +18 more
TL;DR: Three newly diagnosed xeroderma pigmentosum complementation group G patients with markedly different clinical features showed marked reductions in post-ultraviolet cell survival and DNA repair but these were higher in XP65BE than in XP82DC, and XP96TA fibroblasts had very low XPG mRNA expression levels whereasXP65BE fibroblast levels had nearly normal levels.
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