Susanne C. Beck
University of Tübingen
71 Papers
614 Citations
Susanne C. Beck is an academic researcher from University of Tübingen. The author has contributed to research in topics: Retinal & Retina. The author has an hindex of 32, co-authored 69 publications.
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Papers
A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy.
Marcel V. Alavi,Stefanie Bette,Simone Schimpf,Frank Schuettauf,Ulrich Schraermeyer,Hans F. Wehrl,Lukas Rüttiger,Susanne C. Beck,Felix Tonagel,Bernd J. Pichler,Marlies Knipper,Thomas Peters,Juergen Laufs,Bernd Wissinger +13 more
TL;DR: A first mouse model carrying a splice site mutation (c.1065 + 5G --> A) in the Opa1 gene, which induces a skipping of exon 10 during transcript processing and leads to an in-frame deletion of 27 amino acid residues in the GTPase domain is reported.
A portable albumin binder from a DNA-encoded chemical library
Christoph E. Dumelin,Sabrina Trüssel,Fabian Buller,Eveline Trachsel,Frank Bootz,Yixin Zhang,Luca Mannocci,Susanne C. Beck,Mihaela Drumea-Mirancea,Mathias W. Seeliger,Christof Baltes,Thomas Müggler,Felicitas Kranz,Markus Rudin,Samu Melkko,Jörg Scheuermann,Dario Neri +16 more
TL;DR: The discovery and characterization of a class of 4-(p-iodophenyl)butyric acid derivatives from a DNA-encoded chemical library, which display a stable noncovalent binding interaction with both mouse serum albumin (MSA) and human serumalbumin (HSA), which was used to improve the performance of the contrast agents fluorescein and GdDTPA.
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Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia
Susanne Kohl,Ditta Zobor,Wei-Chieh Chiang,Nicole Weisschuh,Jennifer Staller,Irene Gonzalez Menendez,Stanley Chang,Susanne C. Beck,Marina Garcia Garrido,Vithiyanjali Sothilingam,Mathias W. Seeliger,Franco Stanzial,Francesco Benedicenti,Francesca Inzana,Elise Héon,Ajoy Vincent,Jill Beis,Tim M. Strom,Günther Rudolph,Susanne Roosing,Anneke I. den Hollander,Frans P.M. Cremers,Irma Lopez,Huanan Ren,Anthony T. Moore,Andrew R. Webster,Michel Michaelides,Robert K. Koenekoop,Eberhart Zrenner,Randal J. Kaufman,Stephen H. Tsang,Bernd Wissinger,Jonathan H. Lin +32 more
TL;DR: Achromatopsia (ACHM) is an autosomal recessive disorder characterized by color blindness, photophobia, nystagmus and severely reduced visual acuity.
Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration
Gesine Huber,Susanne C. Beck,Christian Grimm,Ayse Sahaboglu-Tekgöz,François Paquet-Durand,Andreas Wenzel,Peter Humphries,T. Michael Redmond,Mathias W. Seeliger,M. Dominik Fischer +9 more
TL;DR: Cross-sectional visualization of retinal structures in wild-type mice and mouse models for retinal degeneration in vivo is demonstrated using a commercially available SD-OCT device to facilitate characterization of disease dynamics and evaluation of putative therapeutic effects after experimental interventions.
•Journal Article
Optical Coherence Tomography in Mouse Models of Retinal Degeneration
Gesine Huber,Dominik Fischer,Naoyuki Tanimoto,Susanne C. Beck,Regine Muehlfriedel,E. Fahl,Rod Bremner,Jan Wijnholds,Christian Grimm,M. W. Seeliger +9 more
TL;DR: In this article, a commercially available spectral domain optical coherence tomography (SD-OCT) was used to study mouse models of retinal degeneration in the presence of hereditary retinal atrophy.
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