Steven G. Smith
Icahn School of Medicine at Mount Sinai
10 Papers
17 Citations
Steven G. Smith is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Bromodomain & Chromatin. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Steven G. Smith include Columbia University.
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Papers
The Bromodomain: A New Target in Emerging Epigenetic Medicine
Steven G. Smith,Ming-Ming Zhou +1 more
TL;DR: The bromodomain (BrD) is a conserved protein modular domain found in many chromatin- and transcription-associated proteins that has the ability to recognize acetylated lysine residues and plays a vital role in many acetylation-mediated protein-protein interactions in the cell.
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Structural features and inhibitors of bromodomains
TL;DR: The structural and functional features of the bromodomains and their small-molecule inhibitors are reviewed and additional new insights provided herein highlight the landscape of the ligand binding sites that will hopefully facilitate further development of new inhibitors with optimal affinity and selectivity.
Complement Factor H Y402H polymorphism is associated with an increased risk of mortality after intracerebral hemorrhage.
Geoffrey Appelboom,Matthew Piazza,Brian Y. Hwang,Samuel S. Bruce,Steven G. Smith,Alexander Bratt,Emilia Bagiella,Neeraj Badjatia,Stephan A. Mayer,E. Sander Connolly +9 more
TL;DR: It is concluded that CFH Y402H polymorphism independently predicts mortality at discharge and 6-months and survival duration after spontaneous ICH, and after controlling for pertinent variables identified in the univariate analysis, the CFH genotype independently predicted mortality in complement component 3 C3, complement component 5 C5, and Complement Factor H.
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ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains
TL;DR: ChEpiMod is a free knowledgebase of chemical modulators with documented modulatory activity for epigenome reader domains that can be used to browse existingchemical modulators and bioactivity data, as well as, all available structures of readers and their molecular interactions.
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