Stefan Golfier

TL;DR: This work disentangle mutual contributions of cell size and cell stiffness to cell deformation by a theoretical analysis in terms of hydrodynamics and linear elasticity theory and demonstrates that the analytical model not only predicts deformed shapes inside the channel but also allows for quantification of cell mechanical parameters.

TL;DR: Xenopus egg extracts are used to reconstitute and image loop extrusion of single DNA molecules during the cell cycle to show that loops form in both metaphase and interphase, but with distinct dynamic properties.

TL;DR: The results establish the importance of myosin II as an active component in modulating suspended cell mechanics, with a functional role distinctly different from that for substrate-adhered cells.

TL;DR: Polymer surface mediated condensation reconciles several observations that were previously thought to be at odds with the idea of phase separation as an organizing principle in the nucleus.