GO-based antibacterial composites: Application and design strategies

Understanding the dynamic behavior of hydrogel formation induced by a temperature ramp is essential for the design of gel-based injectable formulation as drug-delivery vehicles. In this study, the dynamic behavior of the hydrogel formation of Pluronic F108 aqueous solutions within different heating rates was explored in both macroscopic and microscopic views. It was discovered that when the heating rate is increased, the gelation temperature window (hard gel region) shrinks and the mechanical strength of the hydrogel decreases. A given system at different heating rates would lead to different crystalline structural evolutions. The time-resolved small-angle X-ray scattering (SAXS) experiments at a heating rate of 10 °C/min disclose that the crystalline structure of micelle packing in the hydrogel exhibits a series of transitions: hexagonal close-packed (HCP) to face-centered cubic (FCC) and body-centered cubic (BCC) structures coexisting and then to the BCC structure along with the increasing temperature. For the system at equilibrium, the BCC structure exclusively dominates the system. Furthermore, the addition of a hydrophobic model drug (ibuprofen) to the F108 aqueous solution promotes hard gel formation at even lower temperatures and concentrations of F108. The SAXS results for the system with ibuprofen at a heating rate of 10 °C/min demonstrate a mixture of FCC and BCC structures coexisting over the whole gelation window compared to the BCC structure that exclusively dominates the system at equilibrium. The addition of ibuprofen would alter the structural evolution to change the delivery path of the encapsulated drug, which is significantly related to the performance of drug release.

Dynamic Behavior of the Structural Phase Transition of Hydrogel Formation Induced by Temperature Ramp and Addition of Ibuprofen.

A novel method has been successfully developed for creating supramolecula rmetallogels using zinc(II) ions and 5-aminoisophthalic acid as the gelator (low molecular weight gelator) in a dimethylformamide (DMF) solvent at...

5-aminoisophthalic acid low molecular weight gelator based novel Semiconducting Supramolecular Zn(II)-Metallogel: Unlocking Efficient Schottky Barrier Diode for Microelectronics

An outstanding approach for the development of supramolecular metallogel with nickel(II) ion and 5-aminoisophthalic acid as a gelator (LMWG) in DMF medium had been accomplished at room temperature. The rheological...

A Semiconducting Supramolecular novel Ni(II)-Metallogel derived from 5-aminoisophthalic acid low molecular weight gelator: An Efficient Schottky Barrier Diode Application

Soft naturally occurring biodegradable low molecular weight (LMW) gels with high water absorption capacity and inherent antibacterial properties are significant for applications in wound healing patches, personal hygiene products and soft tissue regeneration. Herein, we report novel naturally occurring bile acid based nanocomposite hydrogels derived from sodium deoxycholate (NaDC) and reduced graphene oxide (rGO) as well as amphiphilic sodium dodecylsulfate (SDS) modified rGO. Introduction of rGO and SDS-rGO in the NaDC hydrogel induces π-π stacking in the nanocomposite hydrogels as well as enhances H-bonding interactions significantly yielding long range order as reflected by FTIR, sol-gel transition temperature, XRD, rheology and SEM studies. Among pure NaDC, rGO-NaDC and SDS-rGO NaDC xerogels, the latter is found to exhibit more than 10 times increased water absorption capacity compared to the pure NaDC gels which is attributed to the amphiphilic modification imparting increased H-bonding in the corresponding gel. Highest viscosity of SDS-rGO-NaDC hydrogels followed by rGO-NaDC and pure NaDC hydrogels further confirm the improved interactions. The emergence of antibacterial activity in SDS-rGO gel unlike its precursors as well as pure NaDC and rGO-NaDC gels is assigned to the dehydration induced bacterial cell death resulting from its high water absorption capacity imparted by its enhanced H-bonding. Thus, SDS-rGO NaDC gel obtained through a facile alteration of physical forces exhibiting antibacterial activity along with appreciable water absorption capacity and stability under applied stress indicates its strong applicability in biodegradable and biocompatible antibacterial wound healing patches. 

Amphiphilically Engineered Sodium Deoxycholate Based Nanocomposite Hydrogels with Strong Bactericidal and Water Absorption Characteristics

Fabrication of morphologically modified strong supramolecular nanocomposite antibacterial hydrogels based on sodium deoxycholate with inverted optical activity and sustained release

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Fabrication of morphologically modified strong supramolecular nanocomposite antibacterial hydrogels based on sodium deoxycholate with inverted optical activity and sustained release