Srinath Govindarajan
Ghent University Hospital
21 Papers
54 Citations
Srinath Govindarajan is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: Natural killer T cell & Biology. The author has an hindex of 12, co-authored 20 publications. Previous affiliations of Srinath Govindarajan include Council for Scientific and Industrial Research & Centre for Cellular and Molecular Biology.
Chat about Author
Papers
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1.
Yehudi Bloch,Laura Bouchareychas,Laura Bouchareychas,Romain Merceron,Katarzyna Składanowska,Lien Van den Bossche,Sammy Detry,Srinath Govindarajan,Srinath Govindarajan,Dirk Elewaut,Dirk Elewaut,Filomeen Haerynck,Melissa Dullaers,Iannis E. Adamopoulos,Iannis E. Adamopoulos,Savvas N. Savvides +15 more
TL;DR: A mechanistic paradigm for IL‐23 and IL‐12 is proposed whereby cognate receptor binding to the helical cytokine subunits primes recruitment of the shared receptors via the IL‐ 12p40 subunit.
109
Targeting human epidermal growth factor receptor 2 by a cell-penetrating peptide-affibody bioconjugate.
Srinath Govindarajan,Jeyarajan Sivakumar,Prathyusha Garimidi,Nandini Rangaraj,Jerald M. Kumar,Nalam Madhusudhana Rao,Vijaya Gopal +6 more
TL;DR: The data indicate that AF-based chimeric peptides with nucleic acid binding properties may provide an effective tumor specific strategy to deliver therapeutic nucleic acids.
69
Liposomes for targeting hepatocellular carcinoma: Use of conjugated arabinogalactan as targeting ligand
Sanket M. Shah,Peeyush N. Goel,Ankitkumar S. Jain,Pankaj O. Pathak,S G Padhye,Srinath Govindarajan,Sandipto Ghosh,Pradip Chaudhari,Rajiv P. Gude,Vijaya Gopal,Mangal S. Nagarsenker +10 more
TL;DR: Targeting ability and superior activity of PAG liposomes is established pre-clinically suggesting potential of targeted delivery system for improved treatment of HCC.
44
Design of cholesterol arabinogalactan anchored liposomes for asialoglycoprotein receptor mediated targeting to hepatocellular carcinoma: In silico modeling, in vitro and in vivo evaluation.
Pankaj O. Pathak,Vivek Dhawan,Aniket Magarkar,Reinis Danne,Srinath Govindarajan,Sandipto Ghosh,Frank Steiniger,Pradip Chaudhari,Vijaya Gopal,Alex Bunker,Tomasz Róg,Alfred Fahr,Mangal S. Nagarsenker +12 more
TL;DR: A novel methodology was used to guide the determination of the optimal composition of the targeting liposomes: molecular dynamics simulation that aided the understanding of the behaviour of the ligand within the bilayer, thus providing conclusive evidence of targeting potential for formulated nanosystems.
33
Gene delivery into human cancer cells by cationic lipid-mediated magnetofection.
Srinath Govindarajan,Kumiko Kitaura,Makoto Takafuji,Hirotaka Ihara,Komanduri S. Varadarajan,Anant B. Patel,Vijaya Gopal +6 more
TL;DR: The observations clearly indicate enhanced transfection efficiency in vitro, upon magnetofection, in the presence of serum as seen from β-Gal reporter gene expression, and the observed activity in serum suggests the suitability of MNPs for in vivo applications.
33