Siegfried Weiss
Hannover Medical School
34 Papers
243 Citations
Siegfried Weiss is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Interferon & Biology. The author has an hindex of 18, co-authored 33 publications. Previous affiliations of Siegfried Weiss include University of Duisburg-Essen.
Chat about Author
Papers
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells
Laura Schaupp,Sabine Muth,Leif Rogell,Michael Kofoed-Branzk,Felix Melchior,Stefan Lienenklaus,Stephanie C. Ganal-Vonarburg,Matthias Klein,Fabian Guendel,Tobias Hain,Kristian Schütze,Ulrike Grundmann,Vanessa Schmitt,Martina Dorsch,Julia Spanier,Pia-Katharina Larsen,Thomas Schwanz,Sven Jäckel,Christoph Reinhardt,Tobias Bopp,Sven Danckwardt,Karsten Mahnke,Gitta Anne Heinz,Mir-Farzin Mashreghi,Pawel Durek,Ulrich Kalinke,Oliver Kretz,Oliver Kretz,Tobias B. Huber,Siegfried Weiss,Christoph Wilhelm,Andrew J. Macpherson,Hansjörg Schild,Andreas Diefenbach,Hans Christian Probst +34 more
TL;DR: It is reported that the indigenous microbiota controls constitutive production of type I interferons (IFN-I) by plasmacytoid DCs in mice, and tonic IFNAR signaling instructs a specific epigenomic and metabolic basal state that poises cDCs for future pathogen combat.
202
Interleukin-23–Dependent γ/δ T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice
Annika Reinhardt,Tetyana Yevsa,Tim Worbs,Stefan Lienenklaus,Inga Sandrock,Linda Oberdörfer,Thomas Korn,Siegfried Weiss,Reinhold Förster,Immo Prinz +9 more
TL;DR: This study investigated the presence of γ/δ T cells in the enthesis to investigate the pathogenesis of spondyloarthritides and the role of interleukin‐23 in this group of rheumatic diseases.
188
Protective Role of Beta Interferon in Host Defense against Influenza A Virus
TL;DR: The resistance of Mx-BKO mice to influenza A virus strain PR/8/34 (H1N1) was also substantially reduced, demonstrating that IFN-β plays an important role in the defense against influenza Airus that cannot be compensated for by IFn-α.
187
La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian Hosts
Gjon Blakqori,Sophie Delhaye,Matthias Habjan,Carol D. Blair,Irma Sanchez-Vargas,Ken E. Olson,Ghassem Attarzadeh-Yazdi,Rennos Fragkoudis,Alain Kohl,Ulrich Kalinke,Siegfried Weiss,Thomas Michiels,Peter Staeheli,Friedemann Weber +13 more
TL;DR: It is demonstrated that mosquito cells persistently infected with LACV do not undergo apoptosis and mount a specific RNAi response and indicates that NSs has no function in the insect vector.
184
CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-β.
TL;DR: It is shown that the migration of neutrophils is influenced by endogenous interferon‐beta (IFN‐β) via regulation of such chemokines and their receptor, which adds a novel functional aspect of the type I IFN system as effector molecules of natural cancer surveillance and open interesting possibilities for antineutrophil therapies against cancer.
172