Siddhesh Aras
Wayne State University
40 Papers
62 Citations
Siddhesh Aras is an academic researcher from Wayne State University. The author has contributed to research in topics: Biology & Mitochondrion. The author has an hindex of 12, co-authored 22 publications. Previous affiliations of Siddhesh Aras include LSU Health Sciences Center New Orleans.
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Papers
Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2
Siddhesh Aras,Oleg Pak,Natascha Sommer,Russell L. Finley,Maik Hüttemann,Norbert Weissmann,Lawrence I. Grossman +6 more
TL;DR: Three transcription factors are identified that bind a highly conserved 13-bp sequence in the proximal promoter of COX4I2 that functions as an oxygen responsive element (ORE), maximally active at a 4% oxygen concentration.
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.
TL;DR: This MNRR1-mediated stress response may provide an important survival mechanism for cells under conditions of oxidative or hypoxic stress, both in the acute phase by altering mitochondrial oxygen utilization and in the chronic phase by promoting COX remodeling.
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Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing
Natascha Sommer,Maik Hüttemann,Oleg Pak,Susan Scheibe,Fenja Knoepp,Christopher Sinkler,Monika Malczyk,Mareike Gierhardt,Azadeh Esfandiary,Simone Kraut,Felix Jonas,Christine Veith,Siddhesh Aras,Akylbek Sydykov,Nasim Alebrahimdehkordi,Klaudia Giehl,Matthias Hecker,Ralf P. Brandes,Werner Seeger,Friedrich Grimminger,Hossein Ardeschir Ghofrani,Ralph T. Schermuly,Lawrence I. Grossman,Norbert Weissmann +23 more
TL;DR: Cox4i2 is essential for acute but not chronic pulmonary oxygen sensing by triggering mitochondrial hyperpolarization and release of mitochondrial superoxide which, after conversion to hydrogen peroxide, contributes to cellular membrane depolarization, HPV and HPV.
101
Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology
Maik Hüttemann,Icksoo Lee,Xiufeng Gao,Petr Pecina,Alena Pecinova,Jenney Liu,Siddhesh Aras,Natascha Sommer,Thomas H. Sanderson,Monica Tost,Frauke Neff,Juan Antonio Aguilar-Pimentel,Lore Becker,Beatrix Naton,Birgit Rathkolb,Jan Rozman,Jack Favor,Wolfgang Hans,Cornelia Prehn,Oliver Puk,Anja Schrewe,Minxuan Sun,Heinz Höfler,Jerzy Adamski,Raffi Bekeredjian,Jochen Graw,Thure Adler,Dirk H. Busch,Martin Klingenspor,Thomas Klopstock,Markus Ollert,Eckhard Wolf,Helmut Fuchs,Valerie Gailus-Durner,Martin Hrabě de Angelis,Norbert Weissmann,Jeffrey W. Doan,David J. P. Bassett,Lawrence I. Grossman +38 more
TL;DR: The data suggest that high activity lung COX is a central determinant of airway function and is required for maximal airway responsiveness and healthy lung function, and proposes mitochondrial oxidative phosphorylation as a novel target for the treatment of respiratory diseases, such as asthma.
79
Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells
Stephanie Lucas,Guohua Chen,Siddhesh Aras,Jian Wang +3 more
- 01 May 2018
TL;DR: Using CRISPR-Cas9 gene editing, it is demonstrated that the mitochondrial SHMT enzyme, SHMT2, is essential to maintain cellular respiration, the main process through which mammalian cells acquire energy.
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