Shantha Kodihalli
St. Jude Children's Research Hospital
17 Papers
296 Citations
Shantha Kodihalli is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Virus & Antibody. The author has an hindex of 8, co-authored 9 publications.
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Papers
Characterization of Avian H5N1 Influenza Viruses from Poultry in Hong Kong
Kennedy F. Shortridge,Nan Nan Zhou,Yi Guan,Peng Gao,Toshihiro Ito,Yoshihiro Kawaoka,Shantha Kodihalli,Scott Krauss,D. Markwell,K.G. Murti,M. Norwood,Dennis A. Senne,L. Sims,Ayato Takada,Robert G. Webster +14 more
TL;DR: The analysis of the antigenic and biological properties of the H5N1 influenza viruses isolated from chickens, ducks, and geese from farms and poultry markets in Hong Kong during 1997 and compares them with those of virus isolated from the index human case revealed limited antigenic drift in 15 years.
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Cross-protection among lethal H5N2 influenza viruses induced by DNA vaccine to the hemagglutinin.
TL;DR: It is shown that gene gun delivery of DNA encoding an H5 HA protein confers complete immune protection to chickens challenged with lethal H5 viruses, and the efficacy of HA-DNA influenza virus vaccine in mice extends to chickens and probably to other avian species as well.
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Amino Acid Residues Contributing to the Substrate Specificity of the Influenza A Virus Neuraminidase
Darwyn Kobasa,Shantha Kodihalli,Ming Luo,Maria R. Castrucci,Isabella Donatelli,Yasuo Suzuki,Takashi Suzuki,Yoshihiro Kawaoka,Yoshihiro Kawaoka +8 more
TL;DR: This finding suggests that the adaptation of NA to different substrates occurs by a mechanism of amino acid substitutions that subtly alter the conformation of NA in and around the active site to facilitate the binding of different species of sialic acid.
148
DNA Vaccine Encoding Hemagglutinin Provides Protective Immunity against H5N1 Influenza Virus Infection in Mice
TL;DR: It is reported that a DNA vaccine encoding hemagglutinin from the index human influenza isolate A/HK/156/97 provides immunity against H5N1 infection of mice, and it is determined that unadapted H5n1 viruses are pathogenic in mice, which provides a well-defined mammalian system for immunological studies of lethal avian influenza virus infection.
147
•Journal Article
Growth and immunogenicity of influenza viruses cultivated in Vero or MDCK cells and in embryonated chicken eggs.
TL;DR: The results suggest that mammalian cells are a viable option for the production of influenza virus vaccines.
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