Sergey A. Popov
National Iranian Oil Company
14 Papers
38 Citations
Sergey A. Popov is an academic researcher from National Iranian Oil Company. The author has contributed to research in topics: Chemistry & Betulin. The author has an hindex of 8, co-authored 14 publications.
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Papers
Design and linkage optimization of ursane-thalidomide-based PROTACs and identification of their targeted-degradation properties to MDM2 protein.
Zhiwen Qi,Guliang Yang,Tao Deng,Jianmin Wang,Hao Zhou,Sergey A. Popov,Elvira E. Shults,Chengzhang Wang +7 more
TL;DR: In this paper, the design, synthesis and cellular activity of six UA PROTAC hydrochloride compounds 1A-1F, in which UA acts as the binding ligand of the PROTAC and is linked to thalidomide (E3 ligand) through a series of synthetic linkers.
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Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives
Chan Woo Lee,Nok Hyun Park,Jin Woong Kim,Byung-Hun Um,Alexander V. Shpatov,Elvira E. Shults,I. V. Sorokina,Sergey A. Popov +7 more
TL;DR: Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid) in UVB irradiation assay.
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Selecting a Green Strategy on Extraction of Birch Bark and Isolation of Pure Betulin Using Monoterpenes
Alexandr E. Grazhdannikov,Lyubov M. Kornaukhova,Vladimir I. Rodionov,Natalia A. Pankrushina,Elvira E. Shults,Anne Sylvie Fabiano-Tixier,Sergey A. Popov,Farid Chemat +7 more
TL;DR: In this article, a sustainable approach to pure betulin extraction using green low-polar solvents from natural feedstock was proposed, including green solvent (ethyl acetate, EtOAc), saponification of the extract, and purification of betulin in limonene or hydrogenated monoterpenes.
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Lupane-type conjugates with aminoacids, 1,3,4- oxadiazole and 1,2,5-oxadiazole-2-oxide derivatives: Synthesis, anti-inflammatory activity and in silico evaluation of target affinity.
Sergey A. Popov,Marya D. Semenova,Dmitry S. Baev,Irina V. Sorokina,N. A. Zhukova,T. S. Frolova,Tatyana G. Tolstikova,Elvira E. Shults,Māris Turks +8 more
TL;DR: The novelty of the present work is the development of new class of low toxic anti-inflammatory substances consisting of amino acid-linked betulonic acid - oxadiazole conjugates which can be considered as prospective chemopreventive agents.
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Electrosynthesis of Stable Betulin-Derived Nitrile Oxides and their Application in Synthesis of Cytostatic Lupane-Type Triterpenoid-Isoxazole Conjugates
Jevgeņija Lugiņina,Martin Lindén,Māris Bazulis,Viktors Kumpiņš,Anatoly Mishnev,Sergey A. Popov,Tatiana S. Golubeva,Siegfried R. Waldvogel,Elvira E. Shults,Māris Turks +9 more
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