Scott J. Hebbring
Marshfield Clinic
111 Papers
700 Citations
Scott J. Hebbring is an academic researcher from Marshfield Clinic. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 34, co-authored 100 publications. Previous affiliations of Scott J. Hebbring include University of Wisconsin-Madison & Mayo Clinic.
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Papers
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Lars G. Fritsche,Wilmar Igl,Jessica N. Cooke Bailey,Felix Grassmann,Sebanti Sengupta,Jennifer L. Bragg-Gresham,Kathryn P. Burdon,Scott J. Hebbring,Cindy Wen,Mathias Gorski,Ivana K. Kim,David Cho,Donald J. Zack,Donald J. Zack,Eric H. Souied,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Elisa Bala,Kristine ELee,David J. Hunter,Rebecca J. Sardell,Paul Mitchell,Joanna E. Merriam,Valentina Cipriani,Valentina Cipriani,Joshua D. Hoffman,Tina Schick,Yara T. E. Lechanteur,Robyn H. Guymer,Matthew P. Johnson,Yingda Jiang,Chloe M. Stanton,Gabri'lle H.S. Buitendijk,Xiaowei Zhan,Xiaowei Zhan,Alan M. Kwong,Alexis Boleda,Matthew Brooks,Linn Gieser,Rinki Ratnapriya,Kari Branham,Johanna R. Foerster,John R. Heckenlively,Mohammad Othman,Brendan J. Vote,Helena Liang,Emmanuelle Souzeau,Ian L. McAllister,Timothy Isaacs,Janette Hall,Stewart Lake,David A. Mackey,David A. Mackey,David A. Mackey,Ian J. Constable,Jamie E Craig,Terrie Kitchner,Zhenglin Yang,Zhenglin Yang,Zhiguang Su,Hongrong Luo,Daniel Chen,Hong Ouyang,Ken Flagg,Danni Lin,Guanping Mao,Henry Ferreyra,Klaus Stark,Claudia N von Strachwitz,Armin Wolf,Caroline Brandl,G. Rudolph,Matthias Olden,Margaux A. Morrison,Denise J. Morgan,Matthew Schu,Jeeyun Ahn,Giuliana Silvestri,Evangelia E. Tsironi,Kyu Hyung Park,Lindsay A. Farrer,Anton Orlin,Alexander J. Brucker,Mingyao Li,Christine A. Curcio,Saddek Mohand-Sa'd,José-Alain Sahel,Isabelle Audo,Mustapha Benchaboune,Angela J. Cree,Christina A Rennie,S. V. Goverdhan,Michelle Grunin,Shira Hagbi-Levi,Peter A. Campochiaro,Nicholas Katsanis,Frank G. Holz,Frédéric Blond,Frédéric Blond,Frédéric Blond,Hél'ne Blanché,Jean Fran ois Deleuze,Robert P. Igo,Barbara Truitt,Neal S. Peachey,Neal S. Peachey,Stacy M. Meuer,Chelsea E. Myers,Emily L. Moore,Ronald Klein,Michael A. Hauser,Eric A. Postel,Monique D. Courtenay,Stephen G. Schwartz,Jaclyn L. Kovach,William K. Scott,Gerald Liew,Ava Grace Tan,Bamini Gopinath,John C. Merriam,R. Theodore Smith,R. Theodore Smith,Jane C. Khan,Jane C. Khan,Jane C. Khan,Humma Shahid,Humma Shahid,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,J Allie McGrath,Renee Laux,Milam A. Brantley,Anita Agarwal,Lebriz Ersoy,Albert Caramoy,Thomas Langmann,Nicole T.M. Saksens,Eiko Kde Jong,Carel B. Hoyng,Melinda Cain,Andrea J. Richardson,Tammy M. Martin,John Blangero,Daniel E. Weeks,Bal Dhillon,Cornelia M. van Duijn,Kimberly F. Doheny,Jane Romm,Caroline C W Klaver,Caroline Hayward,Michael B. Gorin,Michael L. Klein,Paul N. Baird,Anneke I. den Hollander,Sascha Fauser,John R. WYates,John R. WYates,John R. WYates,Rando Allikmets,Jie Jin Wang,Debra A. Schaumberg,Debra A. Schaumberg,Barbara E.K. Klein,Stephanie A. Hagstrom,Itay Chowers,Andrew J. Lotery,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Kang Zhang,Kang Zhang,Murray H. Brilliant,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Anand Swaroop,Emily Y. Chew,Margaret A. Pericak-Vance,Margaret M. DeAngelis,Dwight Stambolian,Jonathan L. Haines,Sudha K. Iyengar,Bernhard H. F. Weber,Gon'alo R. Abecasis,Iris M. Heid +185 more
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
Comparison of RNA-seq and microarray-based models for clinical endpoint prediction.
Wenqian Zhang,Ying Yu,Falk Hertwig,Falk Hertwig,Jean Thierry-Mieg,Wenwei Zhang,Danielle Thierry-Mieg,Jian Wang,Cesare Furlanello,Viswanath Devanarayan,Jie Cheng,Youping Deng,Barbara Hero,Huixiao Hong,Meiwen Jia,Li Li,Simon Lin,Yuri Nikolsky,André Oberthuer,Tao Qing,Zhenqiang Su,Ruth Volland,Charles Wang,May D. Wang,Junmei Ai,Davide Albanese,Shahab Asgharzadeh,Smadar Avigad,Wenjun Bao,Marina Bessarabova,Murray H. Brilliant,Benedikt Brors,Marco Chierici,Tzu-Ming Chu,Jibin Zhang,Richard Grundy,Min Max He,Scott J. Hebbring,Howard L. Kaufman,Samir Lababidi,Lee Lancashire,Yan Li,Xin X. Lu,Heng Luo,Heng Luo,Xiwen Ma,Baitang Ning,Rosa Noguera,Martin Peifer,John H. Phan,Frederik Roels,Frederik Roels,Carolina Rosswog,Susan Shao,Jie Shen,Jessica Theissen,Gian Paolo Tonini,Jo Vandesompele,Po-Yen Wu,Wenzhong Xiao,Joshua Xu,Weihong Xu,Jiekun Xuan,Yong Yang,Zhan Ye,Zirui Dong,Ke Zhang,Ye Yin,Chen Zhao,Yuanting Zheng,Russell D. Wolfinger,Tieliu Shi,Linda H. Malkas,Frank Berthold,Frank Berthold,Jun Wang,Weida Tong,Leming Shi,Leming Shi,Zhiyu Peng,Matthias Fischer,Matthias Fischer +81 more
TL;DR: It is demonstrated thatRNA-seq outperforms microarrays in determining the transcriptomic characteristics of cancer, while RNA-seq and microarray-based models perform similarly in clinical endpoint prediction.
A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.
Goutham Narla,Analisa DiFeo,Helen L. Reeves,Daniel J. Schaid,Jennifer Hirshfeld,Eldad Hod,Amanda Katz,William B. Isaacs,Scott J. Hebbring,Akira Komiya,Shannon K. McDonnell,Kathleen E. Wiley,Steven J. Jacobsen,Sarah D. Isaacs,Patrick C. Walsh,S. Lilly Zheng,Bao Li Chang,Danielle M. Friedrichsen,Janet L. Stanford,Elaine A. Ostrander,Arul M. Chinnaiyan,Mark A. Rubin,Jianfeng Xu,Stephen N. Thibodeau,Scott L. Friedman,John A. Martignetti +25 more
TL;DR: These results are the first to identify a novel mechanism of self-encoded tumor suppressor gene inactivation and link a relatively common single nucleotide polymorphism to both regulation of alternative splicing and an increased risk in a major human cancer.
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Phenotype risk scores identify patients with unrecognized Mendelian disease patterns
Lisa Bastarache,Jacob J. Hughey,Scott J. Hebbring,Joy E. Marlo,Wanke Zhao,Wanting T. Ho,Sara L. Van Driest,Tracy L. McGregor,Jonathan D. Mosley,Quinn S. Wells,Michael Temple,Andrea H. Ramirez,Robert J. Carroll,Travis J. Osterman,Todd L. Edwards,Douglas M. Ruderfer,Digna R. Velez Edwards,Rizwan Hamid,Joy D. Cogan,Andrew M. Glazer,Wei-Qi Wei,QiPing Feng,Murray H. Brilliant,Zhizhuang Joe Zhao,Nancy J. Cox,Dan M. Roden,Joshua C. Denny +26 more
TL;DR: An approach that aggregates phenotypes on the basis of patterns described by Mendelian diseases is described, which can augment rare-variant interpretation and may identify subsets of patients with distinct genetic causes for common diseases.
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
Catherine Tcheandjieu,Xiang Zhu,Austin T. Hilliard,Shoa L. Clarke,Valerio Napolioni,Shining Ma,Myung M. Lee,Huaying Fang,Fei Chen,Yingchang Lu,Noah Tsao,Sridharan Raghavan,Satoshi Koyama,Bryan L. Gorman,Marijana Vujkovic,Derek Klarin,Michael Levin,Nasa Sinnott-Armstrong,Genevieve L. Wojcik,Mary E. Plomondon,Thomas M. Maddox,Stephen W. Waldo,Alexander G. Bick,Saiju Pyarajan,Jie Huang,Rebecca J Song,Yuk-Lam Ho,Steven Buyske,Charles Kooperberg,Jeffrey Haessler,Ruth J. F. Loos,Ron Do,Marie Verbanck,Kumardeep Chaudhary,Kari E. North,Christy L. Avery,Mariaelisa Graff,Christopher A. Haiman,Loic Le Marchand,Lynne R. Wilkens,Joshua C. Bis,Hampton L. Leonard,Botong Shen,Leslie A. Lange,Ayush Giri,Ozan Dikilitas,Iftikhar J. Kullo,Ian B. Stanaway,Gail P. Jarvik,Adam S. Gordon,Scott J. Hebbring,Bahram Namjou,Kenneth M. Kaufman,Kaoru Ito,Kazuyoshi Ishigaki,Yoichiro Kamatani,Shefali S. Verma,Marylyn D. Ritchie,Rachel L. Kember,Aris Baras,Luca A. Lotta,Sekar Kathiresan,Elizabeth R. Hauser,Donald R Miller,Jennifer Lee,Danish Saleheen,Peter D. Reaven,Kelly Cho,J. Michael Gaziano,Pradeep Natarajan,Jennifer E. Huffman,Benjamin F. Voight,Daniel J. Rader,Kyong-Mi Chang,Julie Lynch,Scott M. Damrauer,Peter W.F. Wilson,Hua Tang,Yan V. Sun,Philip S. Tsao,Christopher J. O'Donnell,Themistocles L. Assimes +81 more
TL;DR: A genome-wide association study of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which existing studies are integrated with data from cohorts of white, Black and Hispanic individuals from the Million Veteran Program as mentioned in this paper .
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