Sarah J George
Bristol Royal Infirmary
130 Papers
763 Citations
Sarah J George is an academic researcher from Bristol Royal Infirmary. The author has contributed to research in topics: Neointima & Medicine. The author has an hindex of 44, co-authored 118 publications. Previous affiliations of Sarah J George include University Hospitals Bristol NHS Foundation Trust & University of Bristol.
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Papers
Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries
TL;DR: It is demonstrated that MMPs are directly involved in atherosclerotic plaque destabilization and clearly show that members of the MMP family have widely differing effects on atherogenesis.
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Activation of Matrix-Degrading Metalloproteinases by Mast Cell Proteases in Atherosclerotic Plaques
TL;DR: In this article, the role of the mast cell proteases tryptase and chymase in activation of matrix-degrading metalloproteinases (MMPs) was investigated.
281
Plaque Rupture After Short Periods of Fat Feeding in the Apolipoprotein E–Knockout Mouse Model Characterization and Effects of Pravastatin Treatment
Jason L. Johnson,Kevin G. S. Carson,Helen Williams,Sharada Karanam,Andrew C. Newby,Gianni D Angelini,Sarah J George,Christopher L. Jackson +7 more
TL;DR: Plaque rupture occurs at high frequency in the brachiocephalic arteries of male apolipoprotein E–knockout mice after 8 weeks of fat feeding and pravastatin treatment inhibits early plaque rupture and is also effective when begun after unstable plaques have developed.
265
Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes.
Andrew C. Newby,Sarah J George,Yasmin Ismail,Jason L. Johnson,Graciela B. Sala-Newby,Anita C Thomas +5 more
TL;DR: In-vitro studies on human monocyte-derivedmacrophages and on foam-cell macrophages generated in vivo suggest the existence of several macrophage phenotypes with distinct patterns of metalloproteinase expression, which could play differing roles in cap, core and aneurysm formation.
External stenting reduces long-term medial and neointimal thickening and platelet derived growth factor expression in a pig model of arteriovenous bypass grafting
Dheeraj Mehta,Sarah J George,Jamie Y. Jeremy,M. Bashar Izzat,KM Southgate,Alan J. Bryan,Andrew C. Newby,Gianni D Angelini +7 more
TL;DR: Reduced medial thickening, neointima formation, and cell proliferation were sustained in externally stented grafts, and these effects were associated with a significant reduction in PDGF expression.
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