Sarah Alter-Wolf
University of Miami
3 Papers
Sarah Alter-Wolf is an academic researcher from University of Miami. The author has contributed to research in topics: B cell & Downregulation and upregulation. The author has an hindex of 3, co-authored 3 publications.
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Papers
Deviation of the B Cell Pathway in Senescent Mice Is Associated with Reduced Surrogate Light Chain Expression and Altered Immature B Cell Generation, Phenotype, and Light Chain Expression
TL;DR: It is shown that aged mice maintain an ordinarily minor pool of early c-kit+ pre-B cells, indicative of poor pre-BCR expression, even as pre- BCR competent early pre- B cells are significantly reduced.
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Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage.
TL;DR: It is shown that phenotypic B1 progenitors are retained in old bone marrow even as B2 B cell precursors are reduced, indicating that the B1 B cell pathway persists during old age in contrast to the B2 pathway.
A Molecular Mechanism for TNF-α–Mediated Downregulation of B Cell Responses
Daniela Frasca,Maria Romero,Alain Diaz,Sarah Alter-Wolf,Michelle Ratliff,Ana Marie Landin,Richard L. Riley,Bonnie B. Blomberg +7 more
TL;DR: It is found that incubation of B cells with TNF-α before LPS stimulation induced TTP, a physiological regulator of mRNA stability of the transcription factor E47, which is crucial for CSR, and B cell function was restored by adding anti–TNF- α Ab to cultured B cells.